Drugs in IBD

Question 1

Aminosalicylate

Answer 1

Mesalazine
Sulfasalazine
Balsalazide (pro-drug of 5-ASA)
Olsalazine

Question 2

Aminosalicylate - MoA

Answer 2

Reduce cytokine + free radical formation
Inhibits prostaglandin synthesis

Question 3

Aminosalicylate - side effects

Answer 3

Blood dyscrasias
Nephrotoxicity
Hypersensitivity
- Itching
- Hives
Yellow/orange body fluids
- Contact lenses may be stained

Question 4

Corticosteroids

Answer 4

Prednisolones
Beclometasone (adjunct to aminosalicylate in mild-moderate UC)
Budesonide
Hydrocortisone
Methylprednisolone

Question 5

Drugs that affect the immune system

Answer 5

Azathioprine
Methotrexate
Ciclosporin
Mercaptopurine
MAbs