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Medicine Year 2 5 > Drugs + HLA types > Flashcards

Drugs + HLA types Flashcards

1
Q

Give a name of a proton pump inhibitor

A

Lansoprazole

Omeprazole

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2
Q

Give a name of a H2 blocker

A

Ranitidine

Cimetidine

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3
Q

Give a name of a DMARD

A

Methotrexate
Sulfasalazine
Hydroxychloroquine
Rituximab

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4
Q

Give an example of an ACE inhibitor

A

Ramipril

Lisinopril

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5
Q

Give an example of an angiotensin receptor blocker

A

Candesartane

Eprosartan

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6
Q

Give an example of a calcium channel blocker

A

Amlodipine

Nifedipine

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7
Q

Give an example of an NSAID

A

Aspirin
Ibuprofen
Salicyclic acid
Diclofenec

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8
Q

Give an example of beta blocker

A

Atenolol

Bisoprolol

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9
Q

Give an example of a thiazide like diuretic

A

Bendroflumethazide

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10
Q

Give an example of a potassium sparing diuretic

A

Spironolactone

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11
Q

How do PPIs work?

A

Irreversible inactivate protein pumps

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12
Q

How do some diuretics work?

A

Inhibit symporters in areas of the kidney nephron so that there is reduced reabsorption of salt from the filtrate

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13
Q

How does heparin work?

A

Anticoagulant, inhibits thrombin and factor X

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14
Q

How do CCBs work?

A

Increase cGMP and reduce intracellular Ca2+

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15
Q

How do statins work?

A

Block rate limiting step in cholesterol pathway

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16
Q

How does aspirin work?

A

Irreversible inactivation of cycloxygenase (COX)

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17
Q

How does ibuprofen work?

A

Completely inhibits arachidonic acid at the active site of COX

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18
Q

How does penicillin work?

A

Inhibits transpeptidases, preventing cross linking and inhibiting bacterial wall synthesis

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19
Q

How do corticosteroids work?

A

Up regulate anti-inflammatory genes and down regulate pro-inflammatory genes

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20
Q

Give an example of an SSRI

A

Fluoxetine

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21
Q

What does SSRI stand for?

A

Selective serotonin reuptake inhibitor

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22
Q

Give an example of a tricyclic antidepressant

A

Amitryptilline

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23
Q

When should we give SSRIs?

24
Q

When should we give tricyclic antidepressants?

25
What does LAMA/SAMA stand for?
Long/short acting muscarinic antagonist
26
What does LABA/SABA stand for?
Long/short acting beta-2-agonist
27
Give an example of a SABA
Salbutamol
28
Give an example of a SAMA
Ipratropium
29
Give an example of a LABA
Salmeterol
30
Give an example of a LAMA
Tiotroponin
31
How does warfarin work?
Blocks formation of vitamin K dependent clotting factors
32
What does an alpha blocker do in BPH?
Decrease smooth muscle tone of prostate and bladder
33
Give an example of an alpha blocker
Tamsulosin
34
What does a 5 alpha reductase inhibitor do in BPH?
Decreases testosterone conversion to dihydrotestosterone, a potent androgen receptor agonist
35
Give an example of a 5 alpha reductase inhibitor
Finasteride
36
What does an oral phosphodiesterase (PDE5) inhibitor do in ED?
Increases cGMP
37
Give an example of a PDE5 inhibitor
Sildenafil
38
What HLA type does T1DM have?
HLA DR3/4
39
What HLA type does coeliac disease have?
HLA DQ2/8
40
What HLA type do spondyloarthropathies have?
HLA B27
41
What HLA type does RA have?
HLA DR4/1
42
What HLA type does SLE have?
HLA B8/DR2/DR3
43
What HLA type does sarcoidosis have?
HLA DRB1/DQB1
44
In what condition is HLA B27 found?
Spondyloarthropathies
45
In what condition is HLA DR3 found?
T1DM, SLE
46
In what condition is HLA DQ8 found?
5% of coeliac disease
47
In what condition is HLA DQB1 found?
Sarcoidosis
48
In what condition is HLA B8 found?
SLE
49
In what condition is HLA DR4 found?
T1DM, RA
50
In what condition is HLA DQ2 found?
95% of coeliac disease
51
In what condition is HLA DRB1 found?
Sarcoidosis
52
In what condition is HLA DR2 found?
SLE
53
In what condition is HLA DR1 found?
RA
54
Give an example of an antiplatelet
Clopidogrel
55
How does clopidogrel work?
Irreversibly binds to ADP receptors (P2Y12) on the surface of platelets, preventing platelet aggregation
56
What does HLA stand for?
Human leukocyte antigen

Medicine Year 2 5 (17 decks)

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