Drugs for Thyroid

Question 1

Thyroid Agents

Answer 1

Levothyroxine (T4)

Liothyroxine (T3)

Question 2

Anti-thyroid Agents

Answer 2

Radioactive Iodine
KI
Methimazole
PTU

Question 3

What can be given to treat the autonomic symptoms of Thyrotoxicosis?

Answer 3

Beta Blocker (Propranolol or Metoprolol)

Question 4

Amiodarone effect on Thyroid

Answer 4

Can cause Type II thyrotoxicosis

Question 5

Type 1 vs Type 2 Amiodarone-induced Thyrotoxicosis

Answer 5

Type 1- Underlying thyroid pathology

Type 2- subacute thyroiditis with release of preformed thyroid hormones

Question 6

What are the Thioamide Meds?

Answer 6

anti-thyroid drugs:
PTU
Methimazole
Carbimazole

Question 7

How do the Thioamides work?

Answer 7

Blocks the action of Thyroperoxidase

Question 8

Potassium Iodide MOA

Answer 8

Blocks Iodine uptake into follicular cells

Question 9

PTU MOA

Answer 9

Inhibits Thyroperoxidase, specifically the conversion of T4 to T3.

Question 10

What is the most sensitive screening test for hyperthyroidism and primary hypothyroidism?

Answer 10

TSH

Question 11

Side effects of Levothyroxine

Answer 11

Weight loss
Heat intolerance
Sweating
Anxiety

*Just remember what happens when there’s too much like in hyperthyroidism

Question 12

Drugs that can impair levothyroxine absorption

Answer 12

Antacids
Iron
Cholestyramine
PPI’s

Question 13

Which two treatments for hyperthyroidism are contraindicated in pregnancy?

Answer 13

Methimazole

Radioactive Iodine

Question 14

In Grave’s disease, the cause of hyperthyroidism is the production of Ab’s that have what action?

Answer 14

Activate TSH receptors in the Thyroid

Question 15

Biggest side effect of methimazole

Answer 15

Agranulocytosis