Adrenal Corticosteroids Flashcards
3 pathologies glucocorticoids help treat
Inflammation
Allergic reactions
Immunological disorders
3 endocrine pathologies corticosteroids help treat
- Cushing’s Syndrome
- Adrenal Insufficiency
- CAH
What enzyme inactivates endogenous steroids?
11B-Dehydrogenase
Steroid treatment for Addison’s Disease and CAH
Hydrocortisone (gluco-) + Fludrocortisone (mineral)
Effects of Glucocorticoids
Decreased PG’s and Leukotrienes
Decreased Neutrophils and Macrophages
Decreased Cytokines
aka: Immunosuppression for the 4th time
Metabolic effects of glucocorticoids
Decreased glucose uptake
Lipolysis
decreased AA uptake
Inhibitors of 11B-HSD2
Licorice root extract (Glycyrrhizin)
Carbenoxolone
Short acting steroids
Hydrocortisone
Cortisone
Intermediate steroids
Prednisone
Prednisolone
Methylprednisolone
Triamcinolone
Long-acting steroids
Betamethasone
Dexamethasone
What glucocorticoid-receptor antagonist can be given to induce a medical abortion?
Mifepristone
How does Ketoconazole work?
Inhibits fungal and mammalian CYP’s which inhibits formation of steroid hormones and fungal ergosterol
