Drugs for test 1

Question 1

Alpha 1 Receptor

Answer 1

Vascular: Contraction

Heart: Increased contractile force

Norepi > epi&raquo_space; Iso

Question 2

Alpha 2 Receptor

Answer 2

Inhibit Norepi release. Decrease sympathetic activation.

Question 3

Beta 1 Receptor

Answer 3

Heart: Increased force and rate of contraction and AV nodal conduction

Question 4

Beta 2 Receptor

Answer 4

Smooth muscle relaxation

Question 5

Pyridostigimine

Answer 5

MoA: Reversible inhibitor of AChase

Clinical Uses: Neurogenic orthostatic hypotension, Myasthenia Gravis

Toxicity: Resp. depression, bradycardia, lacrimation, diarrhea

Question 6

Atropine

Answer 6

MoA: Non-selective muscarinic antagonist

Clinical Uses: Reversal of vagal bradycardia, antidote for AChase inhibitor toxicity.

Toxicity: Tachycardia

Question 7

Clonidine

Answer 7

MoA: A2 agonist in CNS decreasing sympathetic outflow

Clinical Uses: Hypertension

Toxicity: Postural hypotension, bradycardia, sedation, dry mouth

Question 8

Dobutamine

Answer 8

MoA: B1 agonist

Clinical Uses: Increase contractility in heart failure, ardiac stress test

Toxicity: Tachycardia

Question 9

Dopamine

Answer 9

MoA: Dopamine, A1, and B agonist

Clinical Uses: Septic Shock

Toxicity: Tachycardia, vasoconstriction, local necrosis

Question 10

Epinehrine

Answer 10

MoA: A1 and B agonist

Clinical Uses: Cardiac arrest, anaphylaxis

Toxicity: Arrythemia, local necrosis

Question 11

Isoproterenol

Answer 11

MoA: B agonist

Clinical Uses: Limited use in bradycardia

Toxicity: Tachycardia, hypotension

Question 12

Methyldopa

Answer 12

MoA: Selective A2 agonist in CNS decreasing sympathetic outflow

Clinical Uses: Limited use as antihypertensive in pregnancy

Toxicity: Postural hypotension, bradycardia, sedation, dry mouth, impotence

Question 13

Midodrine

Answer 13

MoA: A1 agonist

Clinical Uses: Chronic orthostatic hypotension

Toxicity: Hypertension, bradycardia

Question 14

Norepinephrine

Answer 14

MoA: A and B agonist

Clinical Uses: Restoration of BP in acute hypotensive state

Toxicity: Arrythmia, extravasation necrosis

Question 15

Phenylephrine

Answer 15

MoA: A1 agonist

Clinical Uses: Neurogenic shock, short term vasoconstriction, decongestant

Toxicity: Hypertension, bradycardia

Question 16

Carvedilol

Answer 16

MoA: A1 and B antagaonist

Clinical Uses: Systolic heart failure, hypertension, angina

Toxicity: Bradycardia, AV block, fatigue, bronchoconstriction

Question 17

Doxazosin

Answer 17

MoA: A1 antagonist

Clinical Uses: Benign prostatic hyperplasia, hypertension

Toxicity: Orthostatic hypotension

Question 18

Labetalol

Answer 18

MoA: A1 and B antagonist

Clinical Uses: Pregnancy induced hypertension, hypertensive crisis

Toxicity: bradycardia, bronchoconstriction

Question 19

Metoprolol

Answer 19

MoA: B1 antagonist

Clinical Uses: Systolic heart failure, hypertension, angina

Toxicity: Bradycardia, AV block, fatigue, bronchoconstriction

Question 20

Phentolamine

Answer 20

MoA: A antagonist

Clinical Uses: Treatment of extravasation of adrenergic agonists

Toxicity: Orthostatic hypotension, teachycardia, nasal congestion

Question 21

Phenoxybenzamine

Answer 21

MoA: long-lasting A antagonist

Clinical Uses: Pheochromocytoma

Toxicity: Othostatic hypotension, tachycardia, nasal congestion

Question 22

Propranolol

Answer 22

MoA: B antagonist

Clinical Uses: Angina, arrythmias, essential tremor, performance anxiety, migraine

Toxicity: Bradycardia, bronchoconstriction