Drugs for Multiple Sclerosis

Question 1

Name 3 drugs for the treatment of MS.

Answer 1

Glatiramer
Interferon Beta
Natalizumab

Question 2

What is MS?

Answer 2

MS is an inflammatory, demyelinating disorder of the CNS. It is thought to be autoimmune in nature, follows a relapsing-remitting course and is progressive.

Question 3

What is the MOA of Glatiramer?

Answer 3

Glatiramer (Copaxone) is a synthetic polypeptide. It may block the presentation of certain myelin antigens to T lymphocytes.

Question 4

List 3 adverse effects of Glatiramer.

Answer 4

Injection site reaction
Nausea
Oedema
PP: Some people get flushing, chest pain and palpitations within minutes of the injection, this is normally mild and temporary.

Question 5

What is the daily dose of Glatiramer?

Answer 5

20mg subcutaneous, daily.

Question 6

What is the MOA of Interferon Beta?

Answer 6

Thought to act through immunoregulatory actions including antagonism of gamma interferon, reduction of cytokine kinase and augmentation of suppressor T cell function.

Question 7

List 3 adverse effects of Interferon Beta.

Answer 7

Rash
Flu-like symptoms
Anaemia

Question 8

What is the daily dose of Interferon Beta?

Answer 8

Avonex: IM 30mcg once weekly.
Rebif: maint. 44mcg 3 times per week.

Question 9

What is the MOA of Natalizumab?

Answer 9

Thought to inhibit leukocyte migration from blood into CNS, thus reducing inflammation and demyelination.

Question 10

List 3 adverse effects of Natalizumab.

Answer 10

Infection
Muscle cramps
Fatigue

Question 11

What is the daily dose of Natalizumab?

Answer 11

IV infusion 300mg every 4 weeks.