Anti-inflammatories Flashcards
Name 2 selective COX-2 inhibitors.
Celecoxib
Meloxicam
Name 6 non-selective NSAIDs.
Aspirin Diclofenac Ibuprofen Indomethican Ketoprofen Mefenamic Acid Naproxen Piroxicam
Name 5 precautions of NSAID use.
Dehydration - NSAIDs may reduce renal function and cause AKI.
Asthma - increased risk of bronchospasm.
Coagulation disorders - may increase risk of bleeding.
High CV risk - may increase further.
PUD - may exacerbate.
Name 4 common adverse effects of NSAID use.
Nausea
Dyspepsia
GI ulceration or bleeding
Salt and fluid retention
What is the MOA of celecoxib?
Inhibition of COX-2 results in anti-inflammatory and analgesic effects.
What are 4 common indications for the use of NSAIDs?
Rheumatoid arthritis Osteoarthritis Acute gout Fever Pain
What is the daily dose of Celecoxib?
100-200mg daily
List 2 counselling points for NSAIDs.
Take with food.
Don’t take any other anti-inflammatories.
What is the MOA of non-selective NSAIDs?
Inhibition of COX-2 causes anti-inflammatory and analgesic effects.
Inhibition of prostaglandin synthesis by inhibiting COX-1 and COX-2.
What is the daily dose of Diclofenac?
75-150mg daily in 2-3 divided doses. Maximum 200mg daily.
What is the daily dose of ibuprofen?
200-400mg 3-4 times per day. Maximum 2.4g daily.
What is the daily dose of indomethican?
25-50mg 2-4 times per day.
What is the daily dose of ketoprofen?
200mg once daily.
What is the daily dose of mefenamic acid?
500mg three times per day when required.
What is the daily dose of meloxicam?
7.5-15mg daily.
