Antiplatelet drugs Flashcards
What is the mechanism of action of Dipyridamole?
Inhibits platelet function by inhibiting phosphodiesterase, which increases platelet cAMP.
Name 3 adverse effects of Dipyridamole.
Headache
Hot flushes
Hypotension
Tachycardia
What is the MOA of Clopidogrel?
A prodrug, the active metabolite irreversibly binds to the platelet And inhibits platelet aggregation.
What is the daily dose of dipyridamole for prevention of thromboembolism?
300-600mg daily.
Name 3 indications for Dipyridamole use.
Prevention of thromboembolism.
Secondary prevention of stroke and TIA.
Cardiac stress testing.
Name 2 adverse effects of Clopidogrel.
Diarrhoea
GI ulceration
Name a precaution to Dipyridamole use.
Aortic stenosis, OR
Unstable angina
Name 2 indications for the use of Clopidogrel.
Prevention of CV events in people with atherosclerosis.
Adjuvant reperfusion after STEMI.
What is the daily dose of Clopidogrel?
75mg once daily.
What is the MOA of Aspirin?
Aspirin inhibits platelet aggregation by irreversibly inhibiting COX, causing decreased synthesis of thromboxane A2.
Name 3 indications for aspirin use.
Acute MI
Unstable angina
Primary prevention of stroke and acute MI
Secondary prevention of stroke and TIA
Name 2 precautions for aspirin use.
Allergy to aspirin or other NSAIDs
Aspirin-sensitive asthma
Contraindication: active bleeding disorders
Name 3 adverse effects of aspirin use.
GI irritation
Asymptomatic blood loss
Increased bleeding time
What is the daily dose of aspirin for long term prevention of CV events?
75-150mg daily.
Name 3 common anti-platelet drugs.
Aspirin
Clopidogrel
Dipyridamole
