Drugs For Hypertension Flashcards
1
Q
Follow the ABCD
A
ACE/AT-1 Inhibitors, Beta Blockers, Ca2+ channel inhibitors and Diuretics
2
Q
ACE inhibitors
A
Will inhibit the Angiotensin Converting Enzyme and hence inhibits Angiotensin I to angiotensin II
3
Q
AT-1 inhibitors
A
Will inihibt the AT-1 receptors, the targets of Angiotensin II
4
Q
Actions of AT-1 receptors
A
They are GPCR that promote
- Vasoconstriction
- Aldosterone synthesis
- vasopressin secretion
- Cardiac hypertrophy
- SM cell proliferaton
5
Q
Drugs that block ACE
A
The Pril family
- Captopril
- Enalopril
- Perindopril
- Ramipril
6
Q
Drugs that Block AT-1
A
The Sartan family
- Candsartan
- losartan
- Irbesartan
7
Q
Beta-Blockers Drugs include
A
B1 specific - Atenolol and Metoprolol
B1 and B2 specific - Propanolol and Timolol
Partial B1 and B2 - Pindolol
8
Q
Ca2+ inhibitoris
A
To regulate Blood pressure the Dihydropyradines are used
- Felodipine
- Nifedipine
9
Q
Why do we use Diuretics
A
Are used to remove any excess water in the system to reduce the level of water content in the plasma
10
Q
List of Diuretics
A
Loop acting - Frusemide Thiazides - Indamide - Hydrochlorothiazide - Bendrofluzide K+ sparing - Spirolactone - Triamterene Osmotics - Manitol
