Drugs for Final Flashcards
What class does Alendronate belong to?
Biphosphate
What does Alendronate do?
Blocks bone breakdown and increased BMD.
What are the adverse effects of Alendronate?
Heart attack Nausea, vomiting, diarrhea Metallic taste Esophageal erosion Dental issues Femoral fracture Myalgia Hypocalcemia
What drugs interact with Alendronate?
MVI, iron, antacids, calcium all need to be given separately.
Avoid Aspirin
What do you need to educate you patient on if they are given Alendronate?
Take with a full glass of water on empty stomach in the morning and stay sitting for 30 minutes.
What class does Atorvastatin belong to?
Statin
What is the action of Atorvastatin?
HMG CoA reductase inhibitor
What is Atorvastatin the drug of choice for and why?
Reducing LDL levels
They interfere with the synthesis of cholesterol working at the cellular level
What is the contraindication for Atorvastatin?
Active liver disease or history of alcoholic liver disease
What should you monitor in a patient who is on Atorvastatin?
Liver function tests
What are the adverse effects of Atorvastatin?
Heart attack Dizziness Blurred vision Insomnia Fatigue Cataracts Flatulence Abdominal pain Cramps Nausea Vomiting Constipation
What is the main adverse effect you need to watch for in a patient on Atorvastatin?
Rabdomylosis- muscle pain
What should you educate your patient on if they are taking Atorvastatin?
NO grapefruit juice
Take in the morning
What class does Cholestyramine belong to?
Bile acid sequestrant
What is the method of action for Cholestyramine?
Binds to bile acids in intestine allows excretion in feces instead of reabsorption- causes cholesterol to be iodized in liver and levels to fall
True or false:
Cholestyramine is absorbed systemically.
False:
It is not and is excreted in feces.
What is contraindicated for Cholestyramine?
Complete biliary abstraction, abnormal intestinal function.
What are the adverse effects of Cholestyramine?
Heart attack Fatigue Drowsiness Nausea Constipation INCREASED BLEEDING TIMES Vitamin A and E deficiencies.
What drugs should you not give if the patient is on Chloestyramine?
Thiazide diuretic Digoxin Warfarin thyroid hormones Corticosteroids
What should you educate your patient on if they are on Chloestyramine?
Don’t take with meals.
2 hours before or after meals of other meds.
Do not mix with carbonated beverages.
What class does Hydrochlorothiazide belong to?
Thiazide diuretic
What is the action for Hydrochlorothiazide?
Block the chloride pump. Keeps chloride and sodium in the tubule to be excreted in urine and prevents reabsorption of both into the vascular system.
What is the contraindication for hydrochlorothiazide?
Allergy to sulfonamides and bipolar disorder.
What are the adverse effects for Hydrochlorothiazide?
Decreased calcium excretion Dizzy Vertigo Orthostatic Hypotension Vomiting Anorexia Dry mouth Diarrhea Polyuria Nocturia Muscle cramps or spasms
What can Hydrochlorothiazide cause?
Hyperglycemia
What class does Metoprolol belong to?
Beta blocker
What does Metoprolol do?
Blocks the stimulator effects of the SNS decreasing cardiac output and renin release
What is the use for Metoprolol?
Treatment of stable angina and hypertension, prevents reinfarction in MI patients and treats stable CHF.
What are the contraindications for Metoprolol?
Bradycardia, heart block, cardiogenic shock, asthma, COPD.
What diagnoses should make you use caution when giving Metoprolol?
Diabetes and PVD.
What are the adverse effects of Metoprolol?
Related to the blockage of SNS (CHF, decreased CO, Arrhythmias, dizziness, fatigue, emotional depression, bonchospasm).
What should you not give with Metoprolol?
Clonidine
What may intensify the effect of beta blockers?
Calcium channel blockers like Diltiazem.
What class does Diltiazem belong to?
Calcium channel blocker
What is Diltiazem used for?
Prinzmentals angina
What is the action of Diltiazem?
Inhibits the movement of calcium ions across the membranes of myocardial and arterial muscle cells altering the action potential and blocks contractions.
What diagnoses are contraindicated for use of Diltiazem?
heart block
Sick sinus syndrome
renal or hepatic dysfunction
What are the adverse effects of Diltiazem?
Cardiac arrhthmia
GI upset
Skin reaction
What should you NOT use with Diltiazem?
Grapefruit juice
What class does Exenatide belong to?
Incretin-enhancer GLP-1 Agonist.
What does Exenatide do?
Increases insulin release and decreases glucagon release. Slows gastric emptying and increases satiety.
When should you NOT give Exenatide?
NPO patient Gastroparesis Pregnant or child Renal impairment After a meal
When should you give Exenatide and how?
60minutes of morning and evening meals- SQ
What class does Fluoxetine belong to?
SSRI
What does Fluoxetine do?
Inhibits CNS reuptake of serotonin. Little effect on norepinephrine.
What is Fluoxetine used for?
Depression OCD Panic attacks Bulemia PTSD MCDD Social phobia Anxiety
When is Fluoxetine contraindicated for use?
Impaired renal/hepatic function Cardiac disease Diabetes Severe depression Suicidal patient
What are the adverse effects of Fluoxetine?
Heart attack Drowsiness Insomnia Anxiety Tremor Chest Pain Agitation Sexual Dysfunction Palpitation Increased appetite Hyponatremia
What are the special considerations for Fluoxetine?
Serotonin syndrome and do not stop abruptly
What is serotonin syndrome?
When given with other drugs that increase serotonin. Increased HR and BP, agitation, sweating, hyperthermia, CV collapse, coma, seizures.
What class does Glyburide belong to?
Sulfonylurea
What does Glyburide do?
Stimulates insulin release and improves insulin binding to receptors.
What is contraindicated for Glyburide?
Trauma
Surgery
CV disease
Diabetes type 1
What are the adverse effects of Glyburide?
Hypoglycemia
GI upset
Cardiovascular upset
What interacts with Glyburide?
Beta blockers Garlic Alcohol Anticoagulants Ginseng
What class does Digoxin belong to?
Cardiac glycoside
What does Digoxin do?
Produces an inotropic effect- increasing strength of contraction with increased cardiac output.
Negative chronotropic effect- slowing the heart by decreasing conduction velocity.
What should you check before administering Digoxin?
Apical pulse for 1 full minute
What is Digoxin used for?
CHF, Afib, Atrial flutter, other SVT.
When is Digoxin indicated for use?
Heart block
Renal insufficiency
Hypocalcemia
If you are giving Digoxin via IVP how long should you push it for?
Slowly over 5 minutes
What should you check every 6 months if you are on Digoxin?
Serum levels
What is the reversal drug for Digoxin?
Digoxin immune fab
When should you notify your doctor that something isn’t right when taking Digoxin?
A weight gain of over 2 pounds a day
What class does Escitalopram belong to?
SSRI
What does Escitalopram do?
Increases availability of serotonin at specific postsynaptic receptor sites within the CNS.
What is Escitalopram used for”?
Generalized anxiety and depression
What are the adverse effects for Escitalopram?
Dizziness Nausea Insomnia Somnolence Confusion Seizures
What class does Sertraline belong to?
SSRI
What does Sertraline do?
Inhibits serotonin reuptake
What does Sertraline treat?
Depression OCD Anxiety Panic Social anxiety PMDD PTSD
Do not take Sertraline when?
Taking MAOIs or within 14 days of taking an MAOI
When is the use of Sertraline contraindicated?
Hyponatremia
What are the adverse effects of Sertraline?
Suicidal ideation Seizure Agitation Insomnia Heart attack Dizziness Somnolence Fatigue
What should you monitor when a patient is on Sertraline?
Suicidal ideation and worsening depression
What is Protamine sulfate used for?
antidote for heparin
What class does Furosemide long to?
Loop diuretic
What does Furosemide do?
Blocks the chloride pump in the ascending loop of Henley. Causing reabsorption of sodium and chloride.
What are the adverse effects of Furosemide?
Dizziness Vertigo Paresthesias Orthostatic hypotension Rash Uricaria Nausea Anorexia Vomiting Glycosuria Urinary bladder spasm
What should you report when giving Furosemide?
Tinnitus
Decreased urine output
When can you not take Furosemide?
IF they are allergic to sulfonamide
What does Furosemide mask?
S&S of hypoglycemia
When pushing Furosemide what should you make sure you should do?
PUSH SLOW
What class does Prednisone belong to?
Systemic Corticosteroid
What does Prednisone do?
Suppresses histamine and prostaglandins. Immunosuppressant and anti-inflammatory.
What should you teach your patient when they are prescribed Prednisone?
Take with food
Do NOT stop abruptly
Causes hyperglycemia
Can mask infections
What are the contraindications for use of Prednisone?
Systemic infection Cataracts Peptic ulcer Osteoporosis HTN Renal disease
What are the adverse effects of Prednisone?
Suppresses adrenal gland function Hyperglycemia Cushing syndrome in long term use Mood changes Cataracts Peptic ulcers Hypokalemia Osteoporosis
What class does Nitroglycerin belong to?
Nitrate
What does Nitroglycerin do?
Acts directly on smooth muscle to cause relaxation and depress muscle tone.
What is Nitroglycerin used for?
Prevention and treatment of angina pectoris atacks
When should you NOT give Nitroglycerin?
Cases of severe anemia
Head trauma
Cerebral Hemorrhage
If patient is anemic
When should caution be used after administering Nitroglycerin?
In hypotension, hypovolemia, and any condition limiting CO.
What should you check when administering Nitroglycerin?
BP- if too low do not give
What are the Adverse effects of Nitroglycerin?
Heart attack Dizziness Nausea Vomiting Hypotension Flushing Increased perspiration
What are the drugs that interact with Nitroglycerin?
Ergot derivatives and heparin
What class does Imipramine belong to?
TCA