Drugs for disease 2

Question 1

What are 3 rapid acting insulins

Answer 1

lispro
aspart
glulysine

Question 2

How does insulin aspart modification take place

Answer 2

position B28 proline replaced with negatively charged aspartic acid = faster dissociation

Question 3

what are 3 long acting insulins

Answer 3

glargine
determir
degludec

Question 4

what is glargine also known as

Answer 4

lantus

Question 5

what is detemir also known as

Answer 5

letemir

Question 6

what is degludec also known as

Answer 6

tresiba

Question 7

what is lispro also known as

Answer 7

humalog

Question 8

what is aspart also known as

Answer 8

novorapid

Question 9

what is glulysine also known as

Answer 9

apidra

Question 10

how does insulin glargine modification work

Answer 10

Asparginine residue substituted with glargine at position 21 of A chain

this stabilises hexamer interactions

add 2 arginine residues on c terminus of Beta chain

making it less soluble at pH of subcutaneous tissue

Question 11

what does substituting the asparginine at pos 21do

Answer 11

stabilises hexamer interactions

Question 12

what do adding arginine residues on the c terminus of beta chain

Answer 12

makes it less soluble at ph of subcutaneous tissue

Question 13

what are the 3 regimes

Answer 13

short acting with meals + 3x intermediate acting at night

long acting with meals + 3x rapid + short acting

pump to continously deliver