Drugs for Addiction Flashcards
What is Disulfiram’s mode of action?
Blocks the oxidation of ethanol by inhibiting aldehyde dehydrogenase.
What is Naltrexone’s mode of action?
𝜇-opioid receptor antagonist blocks the reinforcing effects of alcohol on the opioid system and so decreases the craving for alcohol.
What is Acamprosate’s mode of action?
Agonist at GABA-A and antagonist activity at NMDA - mimics the action of alcohol at these receptors.
What 3 drugs are used in alcohol relapse and abstinence?
Disulfiram, Naltrexone and Acamprosate.
What 2 drugs can be combined for increased beneficial effects in alcohol relapse and abstinence?
Naltrexone and Acamprosate.
Which drug causes hangover-like effects when taken with alcohol?
Disulfiram.
Disulfiram should be prescribed in adjunct to what two types of therapy?
Cognitive-behavioural therapy (CBT) and abstinence-based rehab (ARB).
Naltrexone acts on what receptors?
𝜇-opioid.
What type of addiction or withdrawal are Methadone and Buprenorphine for?
Heroin.
When is Methadone given after discontinuation of heroin? (Hours)
8 hours.
When is Buprenorphine given after discontinuation of heroin? (Hours)
6-12 hours.
Buprenorphine acts on what type of receptors?
𝜇-opioid and k-opioid.
Methadone acts on what type of receptors?
𝜇-opioid.
Methadone is given as what formulation?
Oral solution - 15-40mg.
