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Integrated Studies into Mental Health > Anti-Epileptics > Flashcards

Anti-Epileptics Flashcards

1
Q

Irreversible inhibitor of GABA aminotransferase?

A

Vigabatrin.

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2
Q

Drug of choice in absence seizures?

A

Sodium valproate.

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3
Q

What drug used in absence seizures when sodium valproate is not appropriate?

A

Ethosuximide.

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4
Q

SEs = drowsiness, dizziness, weight gain

A

Vigabatrin.

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5
Q

Vigabatrin is useful for what type of seizures?

A

Partial seizures.

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6
Q

Topiramate is effective against which types of seizures? (3)

A

Partial, generalised tonic-clonic and absence seizures.

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7
Q

Topiramate acts on what?

A

Voltage gated Na+ channels.

GABA-A.

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8
Q

Levetiracetam acts on what?

A

SV2A - binds to and alters synaptic neurotransmitter release.

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9
Q

What type of seizure is Levetiracetam used for?

A

Partial seizures.

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10
Q

Tiagabine acts on what?

A

GABA transporter.

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11
Q

What type of seizure is Tiagabine used for?

A

Partial seizures.

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12
Q

What type of seizures are Lamotrigine used for? (3)

A

Partial, tonic-clonic, and absence seizures.

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13
Q

What is Lamotrigine’s mode of action?

A

Inhibits release of glutamate.

Suppresses repetitive neuronal firing by inhibition of Na+ channels.

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14
Q

What type of seizure is Gabapentin effective for?

A

Partial seizures.

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15
Q

What type of ion channels does Gabapentin affect?

A

Ca2+ ion channels.

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16
Q

What is Ethosuximide’s mode of action?

A

Decreases low threshold Ca ion currents.

17
Q

What anti-epileptic is teratogenic?

A

Sodium Valproate.

18
Q

What anti-epileptic is also useful in trigeminal neuralgia and mania?

A

Carbamazepine.

19
Q

What is Carbamazepine’s mode of action?

A

Blocks Na+ channels and decreased neurotransmitter release.

20
Q

How does Phenytoin prevent further action potential generation?

A

By blocking Na+ channels and prolonging their inactive state.

Integrated Studies into Mental Health (7 decks)

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