DRUGS AND BONES Flashcards
0
Q
What derivative of arachidonic acid is often present at inflammatory sites?
A
Cox 2
1
Q
What do most drugs involved in treatment musculoskeletal disease target?
A
Inflammatory cells and inflammatory mediators
2
Q
What is the first step of treatment of RA?
A
NSAIDS and other analgesics (opioids)
These only treat the symptoms
3
Q
What are side effects of cox 2 selective inhibitors?
A
Paradoxically they can can thrombosis
4
Q
What are DMARDs?
A
Disease modifying anti-rheumatic drugs
5
Q
What is the mechanism of methotrexate?
A
Competitive inhibition of dihydrofolate reductase
6
Q
How often is methotrexate taken?
A
Once weekly
7
Q
What are the side effects of methotrexate?
A
Mouth ulcers Nausea Bone marrow suppression Interstitial lung disease Renal failure Hepatitis Acute cutaneous reactions
8
Q
What must you screen for before giving an anti-TNF medication?
A
TB as it can be re activated whilst on these drugs
