Drugs

Question 1

which drug is associated with epididymo-orchitis?

Answer 1

Amiodarone

Question 2

which drug is associated with gingival hypertrophy?

Answer 2

Ciclosporin

Question 3

what is the mechanism of action of anti-metabolite drugs eg. 5-FU?

Answer 3

S phase specific drug, mimics uracil and is incorporated into RNA

Question 4

what is the mechanism of action of anthracyclines eg. doxirubicin?

Answer 4

inhibits DNA and RNA by intercalating base pairs

Question 5

what is the mechanism of action topoisomerase inhibitors eg. etoposide?

Answer 5

Inhibits topoisomerase II, prevents efficient DNA coiling

Question 6

what is the mechanism of action of platinum agents eg. cisplatin?

Answer 6

Crosslinks DNA, this then distorts molecule and induces apoptosis (similar to alkylating agents)

Question 7

what is the mechanism of action of alkylating agents eg. cyclophosphamide?

Answer 7

Phosphoramide mustard forms DNA crosslinks and then cell death

Question 8

what is the mechanism of action of taxanes eg. docetaxal?

Answer 8

Disrupts microtubule formation

Question 9

what cell type does alendronate work on?

Answer 9

osteoclasts

Question 10

which of tamsulosin or finasteride can cause hypotension?

Answer 10

tamsulosin

Question 11

do ace inhibitors cause vasodilation of the afferent or efferent arterioles?

Answer 11

both