Drugs Flashcards
ENDOCRINE
ENDOCRINE
What drugs are used to treat hypopituitarism?
- Growth Hormone (Somatropin)
- DDAVP (desmopressin)
Growth Hormone (Somatropin):
- What is the MOA of somatropin?
- What are the AE associated with GH?
- synthetic GH that has a role in bone, muscle, and organ growth
- fluid retention/edema, muscle and joint pain
DDAVP (desmopressin):
- What class of drug is DDAVP?
- What is the MOA?
- What are the AE?
- What is DDAVP also used to treat?
- What can a deficiency in AVP cause?
- AVP aka ADH, synthetic version
- acts to decrease water excretion by increasing urine concentration. Binds to V2 receptors in collecting ducts causing an increase in AQP channels
- dry mouth, hyponatremia
- nocturnia
- diabetes insipidus
Therapeutic concerns with pituitary treatment:
- Drug treatment accuracy is difficult
- Low GH levels = low bone density which leads to bone fractures
What are the drugs used to treat hyperaldosteronism (mineralocorticoid excess)?
- Spironolactone
- Eplerenone
Spironolactone:
- What is it used to treat?
- What are the AE?
- Is it selective or nonselective for aldosterone receptors? What does this mean?
- What other disease state is this used for?
- Hyperaldosteronism (mineralocorticoid excess)
- Hyperkalemia, lethargy, gynecomastia, menstrual irregularities
- Nonselective, will have more AE than eplerenone
- HTN
Eplerenone:
- What is it used to treat?
- What are the AE?
- Is it selective or nonselective for aldosterone receptors? What does this mean?
- What other disease state is this used for?
- Hyperaldosteronism (mineralocorticoid excess)
- Hyperkalemia, lethargy, gynecomastia, menstrual irregularities
- Selective, it will have less AE than spironolactone
- HTN
What are the drugs used to treat glucocorticoid deficiency?
- Hydrocortisole
- Fludrocortisone
Hydrocortisone and Fludrocortisone:
- What is it used to treat?
- Short term AE?
- Long term AE?
- In primary adrenal insufficiency, why would we replace a mineralocorticoid with flodrocortisone?
- Do we ever increase the dosage with these meds?
- Glucocorticoid deficiency
- increased blood glucose, mood changes, fluid retention
- osteoporosis, thin skin, muscle wasting, poor would healing, adrenal suppression, Cushing’s disease, infection
- to decrease risk of hyperkalemia
- yes, in times of acute stress or even before strenous exercise
Therapeutic concerns with adrenal steroids:
- Catabolic effect on supporting tissues (don’t overload muscles/bones during strengthening)
- May cause HTN due to Na+ retaining properties
- Immunosuppression
- Drug toxicity (mood changes)
What drug is used to treat an androgen deficiency?
-testosterone
Testosterone:
- What is it used to treat?
- Why do we only use it if indicated?
- What does prolonged use lead to?
- What do large doses cause?
- androgen deficiency
- increased risk of MI, stroke, or CV death
- hepatotoxicity
- infertility
What are the 2 main drugs used to treat mens BPH?
- mirabegron (Myrbetriq)
- oxybutynin
Mirabegron (Myrbetriq):
- What class of drug is this?
- What is the MOA?
- What are the AE?
- B3 adrenergic agonist
- relaxes detrusor muscles to decrease voiding symptoms
- may increase BP
Oxybutynin:
- What class of drug is this?
- What is the MOA?
- What are the AE?
- anticholinergic
- antispasmodic effect on smooth muscle, blocks ACh on smooth muscle
- Cant pee, cant see, cant spit, cant shit
Therapeutic concerns with sex hormones:
- Monitor BP due to Na+ and water retention
- Androgen abuse in athletes
What 2 drugs are used to treat hypoparathyroidism?
- Calcium
- Vitamin D
Calcium and vitamin D:
- How much calcium is taken daily for osteoporosis?
- How much vitamin D is taken daily?
- What is the most common AE?
- 1000-1200mg
- 600-800 international units
- constipation
What is the drug used to treat hypothyroidism?
-levothyroxine
Levothyroxine:
- What is this drug used to treat?
- What is the MOA?
- What are the AE?
- Does this drug require monitoring?
- Excessive overdose can increase risk for what?
- Long term overtreatment can lead to what?
- Hypothyroidism
- Synthetic version of T4 that is converted to T3
- OPPOSITE of hypothyroidism symptoms; sweating, heat intolerance, tachycardia, diarrhea, increase basal metabolic rate
- yes, it is an NTI drug (initially every 4-8 weeks, then every 6-12 months)
- MI, HF, angina
- decreased bone density
What drug is used to treat hyperthyroidism?
-Methimazole
Methimazole:
- What is this drug used to treat?
- This drug is preferred over what drug as a antithyroid medication?
- What is the MOA?
- What are the common AE?
- What are the rare AE?
- What is the only reason PTU would be taken over methimazole?
- hyperthyroidism
- PTU (propylthiouracil)
- blocks formation of T4 and T3
- rash, GI upset, arthralgia
- agranulocytosis, hepatotoxicity
- during 1st trimester of pregnancy, methimazole can cause birth defects
Therapeutic concerns about thyroid and parathyroid drugs:
- excessive doses for hyper or hypo tend to produce symptoms of opposite disorder
- avoid overexertion in patient with decreased CO and hypotension caused by hypothyroidism
- excessive doses of calcium can produce arrhythmias
- take advantage of weight bearing activities to stimulate bone formation AND be aware of when high impact should be avioded (osteoporosis)