Drugs Flashcards
mydriatics
- pupil dilation
- stimulates sympathetic (iris dilator contracts) or stimulates parasympathetic (paralyzing iris sphincter muscle)
drug
any substance other than food that alters the physiology of the body via chemical means
Classification of Drugs with Abuse Potential
Schedule 1 - high potential, no medical uses ie) heroin
Schedule 2 - high potential with medical use ie) morphine
Schedule 3 - less potential, accepted medical use ie) barbiturates
Schedule 4 - even less potential, accepted medical use ie) benzodiazepines
Schedule 5 - even less potential, accepted medical use ie) cough syrups
Labelled Indication
FDA approved for a specific disease; can market product for this
Prodrug
- administered in inactive form
- converted by normal metabolic processes in body to active form
Compounding
prepare pharmaceutical preparations not commercially available
Intravitreal injections
- diluted concentration injected into vitreous humor
Subconjunctival injections
- injected under conjectiva
Periocular injections
- injected into tissue around the eye
agonist
- activates a receptor
antagonist
- inhibits a receptor
Adrenergic receptors
- sympathetic nervous system
- alpha & beta
Cholinergic receptors
- muscarinic (parasympathetic) - heart, smooth muscle & iris
- nicotinic - muscle (parasympathetic)
- nicotinic - ganglia (sympathetic)
pharmacodynamics
action of drugs on receptors & tissues (what drug does to body)
pharmacokinetics
study of absorption, distribution, metabolism and excretion of drugs (what body does to the drug)
ADR - Adverse Drug Reaction
Type A - an exaggerated reaction
Type B - rxn not typical from normal pharmacology
Topical anesthetics
- reversible loss of sensation by blocking sensation of pain passing along nerves to brain
- applied externally to tissue
- used if needing to touch cornea
local anesthetics
- reversible loss of sensation by blocking sensation of pain passing along nerves to brain
- injected for local nerve block; externally (lids) or behing eye (retrobulbar)
general anesthetics
- reversible loss of sensation by blocking sensation of pain passing along nerves to brain
- inhalation or intravenously
tropicamide
- cycloplegic drug (mydriatic)
- blocks iris sphincter
phenylephrine
- sympathomimetic agent (adrenergic)
- alpha-1 receptor agonist
- mydriatic (dilates pupil)
- no effect on accomodation
cycloplegic drugs
- mydriatic effect
- parasympatholytic (blocks PNS)
- reduces/paralyzes accomodation
- target ciliary body
cyclopentolate
- stronger cycloplegic drug
Fluorescein (NaFI)
- dye
- used in applanation tonometry
- defects of cornea appear vivid green with cobalt blue filter on slit lamp
- highly susceptible to contamination