Drugs 51-100 Flashcards by Joe Pence

Niacin

Lipid (cholesterol)-lowering

How well did you know this?

Not at all

Perfectly

how does colchicine treat gout

anti inflammation one but doesn’t effect uric acid

How well did you know this?

Not at all

Perfectly

MAB infixes

Cir

Neu

tu = tumor

cir = circulation

neu = neural

li = immune

xi = chimeric

zu = humanized

How well did you know this?

Not at all

Perfectly

Where are Cox1 enzymes found

where are Cox2 enzymes found

Cox 1 are everywhere

Cox2 are inflammation mediated

How well did you know this?

Not at all

Perfectly

examples of AcH-ase inhibitors for Alzheimers (not a very dramatic effect)

ADRs

donazepil

↑parasympathetic function

How well did you know this?

Not at all

Perfectly

important epilepsy drugs to not use in pregnancy

better drugs

trimethadione and divalproex

lamictal or keppra

How well did you know this?

Not at all

Perfectly

Dexlansoprazole

Gastric acid inhibitor

How well did you know this?

Not at all

Perfectly

Risedronate

Osteoporosis

How well did you know this?

Not at all

Perfectly

Amitriptyline

Antidepressant

How well did you know this?

Not at all

Perfectly

IV/IM steroids

dexamethasone

How well did you know this?

Not at all

Perfectly

all triptans increase BP and are CI’ed with known vascular disease.

what is the difference between fovatriptan and sumatriptan

fovatriptan lasts longer

How well did you know this?

Not at all

Perfectly

preventative factors for dementia

education, social interaction, statins(simvastatin), NSAIDs

How well did you know this?

Not at all

Perfectly

dopaminergic drugs used for parkinsons treatment

ADRs

Ergots (bromocriptine)

Non ergots (pramipexoles)

hallucinations (can’t use with psychosis)

How well did you know this?

Not at all

Perfectly

topical steroids

triamcinolone, hydrocortisone, dexamethasone

How well did you know this?

Not at all

Perfectly

one example of an anticholinergic drug used in parkinsons treatment

ADR

Benzotropine

contraindicated in dementia

How well did you know this?

Not at all

Perfectly

ADRs of levo/carbo

involuntary movements, flucutating effectiveness

How well did you know this?

Not at all

Perfectly

IV steroids

methyprednisolone, triamcinalone, dexamethasone

How well did you know this?

Not at all

Perfectly

Pregabalin

Anticonvulsant

How well did you know this?

Not at all

Perfectly

indications for corticosteroids

↓inflammation, immunosuppression

post op nausea

↑wellbeing

accelerated fetal lung growth

How well did you know this?

Not at all

Perfectly

Olanzapine

Antipsychotic

How well did you know this?

Not at all

Perfectly

thiomalate is a gold salt used for RA treatment. what are some common adrs

what is dimercaprol used for

dermatitis, proteinuria

to counteract the ADRs from gold salts

How well did you know this?

Not at all

Perfectly

Rivaroxaban

Anticoagulant

How well did you know this?

Not at all

Perfectly

Famotidine

Gastric acid inhibitor

How well did you know this?

Not at all

Perfectly

what is amantidine best used for

bradykinesia

How well did you know this?

Not at all

Perfectly

Lorazepam

Sedative-antianxiety

Latanoprost

Glaucoma treatment

Fluconazole

Antifungal

Paroxetine

Antidepressant

Allopurinol

Anti-gout

how are MAOIs used in parkinsons treatment what is the risk

they inhibit monoamine oxidase which breaks down dopamine if too much Type A monoamine oxidase is broken down it can cause a hypertensive crisis

pobenecid is used to treat gout. what is the action when shouldn't it be used

blocks uric acid uptake can block NSAID and penicillin secretion

Doxycycline

Antibiotic

main types of prostaglandins

E and F

Pravastatin

Lipid (cholesterol)-lowering

disease modifying drugs for RA

gold salts chloroquin d penicilin

ketrolac is an NSAID useful for what

acute pain IV or IM

what is the function of NMDA antatgonists in Alzheimers treatment (memantidine) ADRs

blocks glutamate receptors, slows progression and can help cognition confusion, agitation, restless

when is lamictal used for epilepsy treatment

it is a common first line agent

Glyburide

Diabetes (type II)

what is the gold standard of care for MS treatment how does it work ADRs/CIs

interferon (avonex) desensitizes immune cells to autoimmune antibodies contraindicated in depression, hepatoxoic

Tamsulosin

Alpha blocker, BPH

Venlafaxine

Antidepressant

aerosol steroids

flunisolide, fluticasone, triamcinolone

Sitagliptin

Diabetes (type II)

ibuprofe and naproxen are what kind of NSAIDs

propionic acid

Diazepam

Sedative-antianxiety

trastuzumab

HER2 MAB for breast cancer

what are chloroquinine and d penilcillaine not commonly used

chloroquinine causes retinopathy and AV/BBB d penicillamine is very toxic

other uses for H1 antihistamines

motion sickness (benedryl) sedation (unisom) antiemesis (phenergan)

what is the action of methotrexate

blocks use of folic acid (not synthesis blocks reduction of folate into folic acid blocks nucleic acid production

etanercept is considered a last resort treatment. why?

because it blocks TNF alpha and beta and significantly increases the risk of infection and cancer

Folic acid

Supplement

what is the benefit of febuxistat over allopurinol

febuxistat is more expensive but more effective, both are usually well tolerated

adalimumab, etanercept, and infliximab are what

TNF alpha inhibitors used for RA treatment

oral steroids

basically any

Prednisone

Corticosteroid, anti-inflammatory

preventative treatment for migraines

propanolol amitryptaline verapamil divalproex

Clonidine

Antihypertensive

when is primadone used to treat epilepsy

pediatrics

three reasons to not use colchicine

they start having diarrhea they are taking aspirin (bad) the are taking a macrolide abx

Lisdexamphetamine

ADHD

antithymocyte antibodies are used to do what

decrase the number of T cells

Estrogen (conjugated)

Menopause

leflunomide is an RA drug what is the action

slows lymphocyte mitosis to reduce pain and swelling

Ranitidine

Gastric acid inhibitor

Pioglitazone

Diabetes (type II)

acute treatment for migraines

NSAIDs cafergot sumatriptan reglan

Fluoxetine

Antidepressant

arachadonic acid + COX = ??? AA + Lipoxygenase = ???

prostaglandins and thromboxans leukotrienes

Levofloxacin

Antibiotic

Mometasone

Corticosteroid, allegies

Penicillin

Antibiotic

Insulin glargine

Insulin (long-acting)

Pantoprazole

Gastric Acid Inhibitor

Alendronate

Osteoporosis

Codeine/APAP

Analgesic-narcotic

what is special about aspirin as an anti-inflammatory important ADRs

it can penetrate brain and tissues its irreversible GI, Renal, anticoagulation

Diltiazem

Antihypertensive (CCB)

Insulin Detemir

Long-acting insulin

infliximab is common used to treat what condition

crohns

carbamazapine is most commonly used in what type of epilepsy ADRs

partial sz hepatotoxic

Thyroid

Thyroid hormone

Oxycodone

Analgesic-narcotic

Insulin aspart

Insulin (rapid-acting)

Lovastatin

Lipid (cholesterol)-lowering

NSAIDs increase risk for what which is probably the safest

CVD naproxin

Triamterene/HCTZ

Diuretic

what is the value of depakote what is the draw back

broad spectrum most teratogenic

Buprenorphine

Narcotic addiction

Ciprofloxacin

Antibiotic

allopurinol and febuxistat are what type of drugs used to treat gout

xanthine oxidase inhibitors

Enalapril

Antihypertensive (ACEI)

ADRs of corticosteroids

adrenal suppression ↓toleratnce of infection ↑hyperglycemia impaired healing avascular necrosis

Naproxen

NSAID

Olmesartan

Antihypertensive (ARB)

glucocortcoids are useful for RA but not good for monotherapy. why

because they are not disease modifying and are long term toxic

Celecoxib

NSAID

omalizumab is a what used for what

Li = immune, xi = chimeric, monoclonal antibodies used as an antihistamine in severe asthmatics

meloxicam is what kind of NSAID

oxicam derived NSAIDs

indoletic acids (indomethacin) are very strong but

they are very GI toxic

Ezetimibe

Lipid (cholesterol)-lowering

topirmate, tiagabine, and gabapentin are what kind of epilepsy drug what types of sz are they used for

gaba modulators topamax is general, the other two are partial

general actions of glucocorticoids

↑blood glucose ↑BP ↓agranulocyte production ↓prostaglandin production

Tolterodine

Incontinence treatment

differentiate between lewy body dementia and early onset parkinsons

lewy body dementia will have frequent hallucinations