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Neuro - Unit 4 > Drugs > Flashcards

Drugs Flashcards

1
Q

Chlorpromazine

  • Drug class?
  • Mechanism?
  • Administration?
  • Absorption?
  • Excretion?
  • AR? (2)
A
  • First generation antipsychotic (>D2/5HT2A) = good against + symptoms
  • Block D2 receptors
  • Oral, IM, IM suspension
  • Incompletely; highly lipid soluble to pass into CNS; CROSS PLACENTA
  • CYP450; excreted via kidney and excreted in BREAST MILK
  • ANS (dry mouth, tachy, constipation, ortho hypo)
    Sedation via musc and hist block
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2
Q

Haloperidol

  • Drug class?
  • Mechanism?
  • Administration?
  • Absorption?
  • Excretion?
  • AR?
A
  • First generation antipsychotic (>D2/5HT2A) = good against + symptoms
  • Block D2 receptors
  • Oral, IM, IM suspension
  • Incompletely; highly lipid soluble to pass into CNS; CROSS PLACENTA
  • CYP450; excreted via kidney and excreted in BREAST MILK
  • EPSE; Dystonia (treat with anti musc.); Akathisia (reduce dose); pseudoparkinsonian (add anti chol or amantidine); tarditive dyskinesia (prevention)
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3
Q

Aripiprazole

  • Drug class?
  • Mechanism?
  • Administration?
  • Absorption?
  • Excretion?
  • AR? (2)
A
  • Second generation antipsychotic (>5HT2A/D2) = good against - symptoms
  • Block D2/5HT2A receptors
  • Oral, IM, IM suspension
  • Incompletely; highly lipid soluble to pass into CNS; CROSS PLACENTA
  • CYP450; excreted via kidney and excreted in BREAST MILK
  • Weight gain, seizures, QT prolongation, photosensitivity, altered thermoreg, neuroleptic malignant syndrome
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4
Q

Clozapine

  • Drug class?
  • Mechanism?
  • Administration?
  • Absorption?
  • Excretion?
  • AR? (2)
A
  • Second generation antipsychotic (>5HT2A/D2) = good against - symptoms
  • Block D2/5HT2A receptors
  • Oral, IM, IM suspension
  • Incompletely; highly lipid soluble to pass into CNS; CROSS PLACENTA
  • CYP450; excreted via kidney and excreted in BREAST MILK
  • AGRANULOCYTOSIS!!! Weight gain, seizures, QT prolongation, photosensitivity, altered thermoreg, neuroleptic malignant syndrome
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5
Q

Olanzapine

  • Drug class?
  • Mechanism?
  • Administration?
  • Absorption?
  • Excretion?
  • AR? (2)
A
  • Second generation antipsychotic (>5HT2A/D2) = good against - symptoms
  • Block D2/5HT2A receptors
  • Oral, IM, IM suspension
  • Incompletely; highly lipid soluble to pass into CNS; CROSS PLACENTA
  • CYP450; excreted via kidney and excreted in BREAST MILK
  • Weight gain, seizures, QT prolongation, photosensitivity, altered thermoreg, neuroleptic malignant syndrome
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6
Q

Quetiapine

  • Drug class?
  • Mechanism?
  • Administration?
  • Absorption?
  • Excretion?
  • AR? (2)
A
  • Second generation antipsychotic (>5HT2A/D2) = good against - symptoms
  • Block D2/5HT2A receptors
  • Oral, IM, IM suspension
  • Incompletely; highly lipid soluble to pass into CNS; CROSS PLACENTA
  • CYP450; excreted via kidney and excreted in BREAST MILK
  • Weight gain, seizures, QT prolongation, photosensitivity, altered thermoreg, neuroleptic malignant syndrome
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7
Q

Risperidone

  • Drug class?
  • Mechanism?
  • Administration?
  • Absorption?
  • Excretion?
  • AR? (2)
A
  • Second generation antipsychotic (>5HT2A/D2) = good against - symptoms
  • Block D2/5HT2A receptors
  • Oral, IM, IM suspension
  • Incompletely; highly lipid soluble to pass into CNS; CROSS PLACENTA
  • CYP450; excreted via kidney and excreted in BREAST MILK
  • Weight gain, seizures, QT prolongation, photosensitivity, altered thermoreg, neuroleptic malignant syndrome
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8
Q

Amitriptyline

  • Drug class?
  • Mechanism?
  • Line?
  • Blood levels?
  • AR?
  • High levels?
A
  • TCAD; Antidepressant
  • Block NET and SERT to prevent reuptake of NE and 5HT
  • Second line
  • Easily monitored
  • Anticholinergic effects (can’t see…), hypotension, weight gain, sexual side effects, sedaton
  • Lethal (arrhythmias and seizures)
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9
Q

Imipramine

  • Drug class?
  • Mechanism?
  • Line?
  • Blood levels?
  • AR?
  • High levels?
A
  • TCAD; Antidepressant
  • Block NET and SERT to prevent reuptake of NE and 5HT
  • Second line
  • Easily monitored
  • Anticholinergic effects (can’t see…), hypotension, weight gain, sexual side effects, sedaton
  • Lethal (arrhythmias and seizures)
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10
Q

Desipramine

  • Drug class?
  • Mechanism?
  • Line?
  • Blood levels?
  • AR?
  • High levels?
A
  • TCAD; Antidepressant
  • Block NET and SERT to prevent reuptake of NE and 5HT
  • Second line
  • Easily monitored
  • Anticholinergic effects (can’t see…), hypotension, weight gain, sexual side effects, sedaton
  • Lethal (arrhythmias and seizures)
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11
Q

Fluoxetine

  • Drug class?
  • Mechanism?
  • Indications?
  • AR: Acute?
  • Delayed? Wtihdrawal?
  • Dangerous mix?
A
  • SSRI’s; Antidepressant
  • Block SERT
  • Many; Anxiety, panic, OCD, PTSD, PDD, GAD
  • P450 inhibition; diarrhea, dry mouth, jitters nausea
  • Cognitive blunting; sexual SE, weight gain
  • SSRI’s and MAOI!!! (hyperthermia, rigid, HTN)
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12
Q

Paroxetine

  • Drug class?
  • Mechanism?
  • Indications?
  • AR: Acute?
  • Delayed? Wtihdrawal?
  • Dangerous mix?
A
  • SSRI’s; Antidepressant
  • Block SERT
  • Many; Anxiety, panic, OCD, PTSD, PDD, GAD
  • P450 inhibition; diarrhea, dry mouth, jitters nausea
  • Cognitive blunting; sexual SE, weight gain
  • SSRI’s and MAOI!!! (hyperthermia, rigid, HTN)
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13
Q

Sertraline

  • Drug class?
  • Mechanism?
  • Indications?
  • AR: Acute?
  • Delayed? Wtihdrawal?
  • Dangerous mix?
A
  • SSRI’s; Antidepressant
  • Block SERT
  • Many; Anxiety, panic, OCD, PTSD, PDD, GAD
  • P450 inhibition; diarrhea, dry mouth, jitters nausea
  • Cognitive blunting; sexual SE, weight gain
  • SSRI’s and MAOI!!! (hyperthermia, rigid, HTN)
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14
Q

Trazodone

  • Drug class?
  • Mechanism?
  • AR?
A
  • Mixed; Antidepressant
  • Complex 5HT mechanism
  • Drowsiness (helps with insomnia)
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15
Q

Mirtazapine

  • Drug class?
  • Mechanism?
  • Advantages? (3)
  • AR? (2)
A
  • Mixed; Antidepressant
  • a2 block to increase NE
  • No insomnia or Sexual SE; rapid anti anxiety
  • Weight gain, daytime somnelence
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16
Q

Bupropion

  • Drug class?
  • Mechanism?
  • Advantages? (2)
  • AR? (4)
  • Contra in?
A
  • Mixed; Antidepressant
  • weak NE-DA reuptake inhibitor
  • No sexual SE; weight neutral
  • Anxiety, ineffective with panic, high seizure risk, insomnia, CONTRA in ANNORHEXICs
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17
Q

Phenelzine

  • Drug class?
  • Mechanism?
  • Effective in?
  • AR? (7)
A
  • MAOI; Antidepressant
  • Inhibit degradation of DA
  • Atypical depression
  • Hypertensive tyramine crises (sausage, wine, cheese), seizures, shock, postural hypo, weight gain, sexual SE, antichol. SE
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18
Q

Venlafaxine

  • Drug class?
  • Mechanism?
  • More effective than?
  • AR? (4)
  • Withdrawal?
A
  • SNRI; Antidepressant
  • Block NET and SERT preventing reuptake
  • TCADs
  • Htx, anxiety, Sexual SE, INCREASED DBP
  • RAPID; flu like electric shock!!!
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19
Q

Electroconvulsive therapy

- Mechanism?

A
  • Antidepressant; Increase tyrosine, tryptophan, tryptophan hydroxylases = more 5HT and NE
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20
Q

Lithium

  • Drug class?
  • Mechanism?
  • Takes how long to work?
  • Use dependent?
  • Also used for?
  • AR? (5)
  • Can increase plasma levels? (2)
A
  • Anti-manic
  • Interferes with recycling of phospho. which decreases action of GCPR’s; Inhibits DA/NE release; Enahnces 5HT release
  • 10-21 days
  • yes
  • preventive
  • Tremor, nausea, diabetes insipidus, hypothyroid, renal effects
  • Narrow therapeutic window
  • Diuretics and NSAIDs
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21
Q

Valproic acid

  • Drug class?
  • Mechanism?
  • AR?
A
  • Anti manic

- Inhibit VSSC

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22
Q

Carbamazepine

  • Drug class?
  • Mechanism?
  • AR?
A
  • Anti manic
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23
Q

Buspirone

  • Drug Class?
  • MOA?
  • Benefits? (2)
  • Absorption?
  • Distribution?
  • Effects order? (4)
  • AR? (3)
A
  • Anxiolytic
  • 5HT1A partial agonist/ some affinity for D2
  • No sedation or additive CNS effects
  • Rapid oral
  • Lipid soluble
  • Axiolysis (sleep and some psychomotor impairment; anticonvulsant; muscle relaxation; hypnosis
  • Amnesia, tolerance, dependence
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24
Q

Diazepam

  • Drug Class?
  • MOA?
  • Usage?
  • Absorption?
  • Distribution?
  • Metabolism?
  • Effects order? (4)
  • AR? (5)
A
  • Anxiolytic BDZ
  • Intensify GABA channel chloride current ONLY if GABA is available on gamma subunit
  • Declining due to abuse potential; more for accute
  • Rapid oral
  • Lipid soluble
  • CYP450 1–>2 then renal
  • Axiolysis (sleep and some psychomotor impairment; anticonvulsant; muscle relaxation; hypnosis
  • Amnesia, tolerance, dependence; additive CNS effects; daytime sedation due to active phase 1 metabolites
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25
Q

Alprazolam

  • Drug Class?
  • MOA?
  • Usage?
  • Absorption?
  • Distribution?
  • Metabolism?
  • Effects order? (4)
  • AR? (5)
A
  • Anxiolytic BDZ
  • Intensify GABA channel chloride current ONLY if GABA is available on gamma subunit
  • Declining due to abuse potential; more for accute
  • Rapid oral
  • Lipid soluble
  • CYP450 1–>2 then renal
  • Axiolysis (sleep and some psychomotor impairment; anticonvulsant; muscle relaxation; hypnosis
  • Amnesia, tolerance, dependence; additive CNS effects; daytime sedation due to active phase 1 metabolites
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26
Q

Lorazepam

  • Drug Class?
  • MOA?
  • Usage?
  • Absorption?
  • Distribution?
  • Metabolism?
  • Effects order? (4)
  • AR? (5)
A
  • Anxiolytic BDZ
  • Intensify GABA channel chloride current ONLY if GABA is available on gamma subunit
  • Declining due to abuse potential; more for accute
  • Reliable IM
  • Lipid soluble
  • NOT CYP450!!! Good for elderly
  • Axiolysis (sleep and some psychomotor impairment; anticonvulsant; muscle relaxation; hypnosis
  • Amnesia, tolerance, dependence; additive CNS effects; daytime sedation due to active phase 1 metabolites
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27
Q

Oxazepam

  • Drug Class?
  • MOA?
  • Usage?
  • Absorption?
  • Distribution?
  • Metabolism?
  • Effects order? (4)
  • AR? (5)
A
  • Anxiolytic BDZ
  • Intensify GABA channel chloride current ONLY if GABA is available on gamma subunit
  • Declining due to abuse potential; more for accute
  • Rapid oral
  • Lipid soluble
  • Not CYP450!!! Good for elderly
  • Axiolysis (sleep and some psychomotor impairment; anticonvulsant; muscle relaxation; hypnosis
  • Amnesia, tolerance, dependence; additive CNS effects; daytime sedation due to active phase 1 metabolites
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28
Q

Flumazenil

  • Drug Class?
  • MOA?
  • Usage?
  • Absorption?
  • Distribution?
  • Metabolism?
  • Effects order? (4)
  • AR? (5)
A
  • Anxiolytic BDZ
  • Intensify GABA channel chloride current ONLY if GABA is available on gamma subunit
  • Declining due to abuse potential; more for accute
  • Rapid oral
  • Lipid soluble
  • CYP450 1–>2 then renal
  • Axiolysis (sleep and some psychomotor impairment; anticonvulsant; muscle relaxation; hypnosis
  • Amnesia, tolerance, dependence; additive CNS effects; daytime sedation due to active phase 1 metabolites
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29
Q

Midazolam

  • Drug Class?
  • MOA?
  • Usage?
  • Absorption?
  • Distribution?
  • Metabolism?
  • Effects order? (4)
  • AR? (5)
A
  • Anxiolytic BDZ
  • Intensify GABA channel chloride current ONLY if GABA is available on gamma subunit
  • Declining due to abuse potential; more for accute
  • Rapid oral
  • Lipid soluble
  • CYP450 1–>2 then renal
  • Axiolysis (sleep and some psychomotor impairment; anticonvulsant; muscle relaxation; hypnosis
  • Amnesia, tolerance, dependence; additive CNS effects; daytime sedation due to active phase 1 metabolites
30
Q

Pentobarbital

  • Drug Class?
  • MOA?
  • Usage?
  • Absorption?
  • Distribution?
  • Metabolism?
  • Effects order? (4)
  • AR? (5)
A
  • Anxiolytic Barbituate
  • Prolong GABA channel even in absence of GABA and decreasing Glu so some anesthetic properties
  • HIGH abuse potential; not really used
  • Rapid oral
  • Lipid soluble
  • CYP450
  • Axiolysis (sleep and some psychomotor impairment; anticonvulsant; muscle relaxation; hypnosis; ANESTHESIA!!!
  • Amnesia, tolerance, dependence; additive CNS effects; CLASSIC CYP450 INDUCER!!!!!
31
Q

Phenobarbital

  • Drug Class?
  • MOA?
  • Usage?
  • Absorption?
  • Distribution?
  • Metabolism?
  • Effects order? (4)
  • AR? (5)
A
  • Anxiolytic Barbituate
  • Prolong GABA channel even in absence of GABA and decreasing Glu so some anesthetic properties
  • HIGH abuse potential; not really used
  • Rapid oral
  • Lipid soluble
  • CYP450
  • Axiolysis (sleep and some psychomotor impairment; anticonvulsant; muscle relaxation; hypnosis; ANESTHESIA!!!
  • Amnesia, tolerance, dependence; additive CNS effects; CLASSIC CYP450 INDUCER!!!!!
32
Q

Xenon

Type of drug?

A
  • Volatile Anesthetic
33
Q

Nitrous oxide

  • Type of drug? (2)
  • Type of substance?
  • MAC? So?
  • 3 related concepts?
  • Use?
A
  • Volatile Anesthetic; Inorganic gas
  • Only true gas (others = volatile liquids)
  • 105%; can’t be used as sole anasthetic (combine with barb/opioid)
  • Conc. effect; diffusion hypoxia; second gas effect
  • Balanced anasthesia
34
Q

Diethyl ether

Type of drug?

A
  • Volatile Anesthetic
35
Q

Cyclopropane

Type of drug? (2)

A
  • Volatile Anesthetic; hyrdocarbon
36
Q

Chloroform

Type of drug? (2)

A
  • Volatile Anesthetic; chlorinated hydrocarbon
37
Q

Halothane (Fluothane®)

  • Type of drug? (2)
  • Potency? Alagesic? Use?
  • Side effects? (4)
A
  • Volatile Anesthetic; fluorinated hydrocarbon
  • High; poor; not anymore
  • Resp. supression; CV arrhythmias; liver failure; malignant hyperthermia with RyR mutation –> treat with Dantrolene
38
Q

Enflurane (Ethrane®)

Type of drug? (2)

A
  • Volatile Anesthetic; fluorinated ether
39
Q

Isoflurane (Forane®)

  • Type of drug?
  • Use?
  • Advantages? (4)
  • Induction?
  • Muscle relaxant?
  • Odor? Triggers? Overcome how?
A
  • Volatile Anesthetic
  • Most widely used
  • More potent; less hepatotoxicity; little seizure propensity; spares heart
  • Rapid/smooth
  • Good
  • Bad; Coughing; IV agents
40
Q

Desflurane (Suprane®)

Type of drug?

A
  • Volatile Anesthetic
41
Q

Sevoflurane (Ultane®)

  • Type of drug?
  • Odor? Used for?
  • Drawback? (2)
A
  • Volatile Anesthetic
  • Good; Induction
  • Chemically unstable; release of fluoride ions may be renal toxic
42
Q

Thiopental(Pentathal®)

Type of drug? (2)

A
  • IV anesthetics; Barbituate
43
Q

Propofol (Diprivan®)

Type of drug?

A
  • IV anesthetics
44
Q

Etomidate (Amidate®)

Type of drug?

A
  • IV anesthetics
45
Q

Ketamine (Ketalar®)

Type of drug? (2)

A
  • Intravenous adjuncts anesthetics; glu receptor agent
46
Q

D-tubocurarine

Type of drug? (2)

A
  • Intravenous adjuncts anesthetics; NM antagonist
47
Q

Morphine (MS-Contin®)

Type of drug? (2)

A
  • Intravenous adjuncts anesthetics; opoid analgesic
48
Q

Fentanyl (Sublimaze®)

Type of drug?

A
  • Intravenous adjuncts anesthetics
49
Q

Diazepam (Valium®)

Type of drug? (2)

A
  • Intravenous adjuncts anesthetics; BDZ
50
Q

Ondansetron (Zorfan®)

Type of drug?

A
  • Intravenous adjuncts anesthetics
51
Q

Glycopyrrolate (Robinul®)

Type of drug?

A
  • Intravenous adjuncts anesthetics
52
Q

Zolpidem

  • Type of drug?
  • MOA?
  • Absorption?
  • Half life?
  • Side effects? (4)
  • Rebound? Psychomotor?
  • Effect on sleep? (2)
  • Generic? Safety?
  • Withdrawal/ dependence?
  • Common?
  • Line?
A
  • “Z” drug for insomnia
  • Bind gamma subunit of ALPHA1!!! (sleep without anxiolysis); facilitates GABA opening
  • Rapid
  • 2-2.5 hours; duration 6-8
  • Drowsy, amnesia, HA; strange sleep behavior
  • No rebound insomnia; no psychomotor impairment
  • ↑ total sleep time; minimal effect on sleep stages III/IV/REM
  • Generic available; good safety profile
  • Withdrawal and dependence possible
  • Most widely prescribed
  • First
53
Q

Zaleplon

  • Type of drug?
  • MOA?
  • Absorption?
  • Half life?
  • Side effects? (4)
  • Rebound? Psychomotor?
  • Effect on sleep? (2)
  • Used for?
A
  • “Z” drug for insomnia
  • Bind gamma subunit of ALPHA1!!! (sleep without anxiolysis); facilitates GABA opening
  • Rapid absorption
  • 1 hour half life
  • HA, dizziness, somnolence; strange sleep behavior
  • No rebound insomnia, No psychomotor impairment
  • ↑ total sleep time; minimal effect on sleep stages III/IV/REM
  • Best sleep aid for middle of night awakenings
  • First
54
Q

Eszoplicone

  • Type of drug?
  • MOA?
  • Absorption?
  • Half life?
  • Side effects? (4)
  • Rebound? Psychomotor?
  • Effect on sleep? (2)
  • Line?
A
  • “Z” drug for insomnia
  • Bind gamma subunit of ALPHA1!!! (sleep without anxiolysis); facilitates GABA opening
  • Rapid
  • 6 hours (longer for longer term use)
  • Drowsy, amnesia, HA; strange sleep behavior
  • No rebound insomnia; no psychomotor impairment
  • ↑ total sleep time; minimal effect on sleep stages III/IV/REM
  • First
55
Q

Triazolam

  • Type of drug?
  • MOA?
  • Absorption?
  • Line?
  • Half life?
  • Dose reduction in?
  • Side effects? (6)
  • Treat toxicity with?
  • Effects on sleep? (4)
A
  • BDZ for insomnia
  • Bind A1 and A2/5 = sleep and anxiolysis
  • Rapid
  • 2nd after Z drugs
  • Short; <5 hours
  • Elderly
  • Rebound insomnia, anterograde amnesia, confusion, hallucination, agitation, bizarre behaviors
  • Flumazenil
  • ↓ sleep latency; ↑ total sleep time; ↑ stage 2; ↓ REM, stage 3, 4
56
Q

Temazepam

  • Type of drug?
  • MOA?
  • Line?
  • Half life?
  • Side effects? (2)
  • Treat toxicity with?
  • Effects on sleep?
A
  • BDZ for insomnia
  • Bind A1 and A2/5 = sleep and anxiolysis
  • Slow
  • 2nd after Z drugs
  • Intermediate; 9-13 hours
  • Rebound insomnia, daytime sedation
  • Flumazenil
  • ↓ sleep latency; ↑ total sleep time; ↑ stage 2; ↓ REM, stage 3, 4
57
Q

Flurazepam

  • Type of drug?
  • MOA?
  • Line?
  • Half life?
  • Metabolite?
  • Side effects? (2)
  • Treat toxicity with?
  • Effects on sleep?
A
  • BDZ for insomnia
  • Bind A1 and A2/5 = sleep and anxiolysis
  • Slow
  • 2nd after Z drugs
  • Long; 75-90 hours
  • Active
  • Daytime sedation
  • Flumazenil
  • ↓ sleep latency; ↑ total sleep time; ↑ stage 2; ↓ REM, stage 3, 4
58
Q

Ramelteon - Melatonin

  • Type of drug?
  • MOA?
  • Decreases latency of sleep?
  • Side effects? (4)
  • Effect on sleep?
A
  • Non-GABA for insomnia
  • MT1/MT2 agonist
  • Yes
  • Dizziness; somnelence; fatigue; nausea
  • Decreases mean latency to sleep
59
Q

Trazodone

  • Type of drug? (2)
  • MOA?
  • Good for what type of patients? Why?
  • Side effects? (3)
  • Effect on sleep?
A
  • Non-GABA for insomnia (Antidepressant)
  • Complicated MOA; inhibits 5HT reupatake
  • Abuse/ addiction; Tolerance/addiction is low
  • Oversedation; orthostasis; priapism (constantly erect penis)
  • ↑ REM sleep
60
Q

Diphenhydramine

  • Type of drug?
  • MOA?
  • Effective for? Advertised by not?
  • Side effects?
A
  • Non-GABA for insomnia; Benadryl
  • H1/M antagonist
  • Short term insomnia; recommended
  • Antimuscarinic in older populations
61
Q

Carbamazepine

  • Type of drug?
  • MOA?
  • Broken down by?
  • Use?
  • SE? (6)
A
  • Anti seizure
  • Inhibits VSSC in use dependent fashion
  • P450
  • Partial Siezures
  • Hepatotoxicity; Hyponatremia; Diplopia; Ataxia; Nausea/vomitting; Steven Johnson
62
Q

Phenytoin

  • Type of drug?
  • MOA?
  • Broken down by?
  • Use?
  • SE? (5)
A
  • Anti seizure
  • Inhibit VSSC in use dependent
  • P450 zero order kinetics
  • Partial
  • Nystagmus!, diplopia, rash!, gingival hyperplasia!, sedation
63
Q

Lamotrigine

  • Type of drug?
  • MOA?
  • Use?
  • SE?
A
  • Anti seizure
  • Unclear
  • Partial and tonic clonic
  • Levels increased by valproate, decreased by OC’s
64
Q

Ethosuximide

  • Type of drug?
  • MOA?
  • Broken down by?
  • Use?
  • SE? (3)
A
  • Anti seizure
  • Inhibit low threshold T-type Ca channel
  • CYP3A4
  • Absence Seizures
  • GI, HA, dizzy
65
Q

Levetriacetam

  • Type of drug?
  • MOA?
  • Use?
  • SE?
A
  • Anti seizure
  • Unknown
  • Partial and tonic clonic
  • Fatigue
66
Q

Valproic Acid

  • Type of drug?
  • MOA?
  • Coated?
  • Use?
  • SE? (5)
A
  • Anti seizure
  • Increases GABA function and limits T type Ca channels
  • Enteric coated
  • Tonic Clonic (Absence but hepatotoxicity bad)
  • Weight gain, hepatotoxicity, CONTRA in PREGNANCY, increases phenobarb levels, decreased plt aggregation
67
Q

Diazepam

  • Type of drug?
  • MOA?
  • Use?
  • SE?
A
  • Anti seizure
  • Ehance GABA
  • Status eppilecticus
  • Tolerance
68
Q

Midazolam

  • Type of drug?
  • MOA?
  • Broken down by?
  • Use?
  • SE? (5)
A
  • Anti seizure
  • Ehance GABA
  • Status eppilecticus
  • Tolerance
69
Q

Lorazapam

  • Type of drug?
  • MOA?
  • Broken down by?
  • Use?
  • SE? (5)
A
  • Anti seizure
  • Ehance GABA
  • Status eppilecticus
  • Tolerance
70
Q

Phenobarbital

  • Type of drug?
  • MOA?
  • Broken down by?
  • Use?
  • SE? (3)
A
  • Anti seizure
  • Enhance GABA, decrease GLU
  • CLASSIC CYP450 INDUCER
  • Neonatal status epilecticus
  • Sedation, irritability, interferes with learning

Neuro - Unit 4 (11 decks)

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