Anxiety Meds

Question 1

• 4 categories of drugs: 1.) 1st line for most? 2.) Used for acute situations? 3.) 5HT1A partial agonist/mod. D2 block? Less SE’s than BDZ’s but? 4.) Rarely used?
  1. ) Generalized Anxiety: %? 1st line? (2) 2nd lines? (3)
  2. ) Social: %? 1st line generalized sad? nongeneralized sad?
  3. ) Panic Disorder: %? Acute attack? Mild? (2) Severe? (2)
  4. ) OCD: %? First line? Then? Severe? (2)
  5. ) PTSD: %? First line? Then? Severe? (2)
• Benefit of Buspirone? PRN use?
• Barbs induce what?

Answer 1

1. ) SSRI’s/SNRI’s 2.) BDZ 3.) Buspirone/ less effective 4.) Barbs
2. ) 5%; SSRI/SNRI or CBT; TCADs/BDZ/Buspirone
3. ) 14%; CBT or SSRI/SNRI; CBT or Propranolol/BDZ
4. ) 4%; BDZ; Anti depress or CBT; both AD and CBT
5. ) 3%; CBT; SSRI; Both CBT and SSRI
6. ) 9% CBT; SSRI; Both CBT and SSRI
   - no sedation or additive depressant effect; no
   - CYP450

Question 2

• Panic disorder: Episodes both somatic and? Pathology? Often with?
• 4 types of patients in increasing commonality?
• Less REM can drive what?
• GABA increasing? (4)
• Glu increasing (4)
• Does not cause sedation drug?
• Barbs bind what top open channel? BDZ bind?
• Increasing dose steps? (4) Barbs only?
• Why BDZ not great for insomnia?
• Doesn’t bind plasma protein (fast breakdown)?
• Fastest metabolism and onset?
• BDZ antagonist?

Answer 2

• psych; amygdala cond. fear; agoraphobia
• Initial somatasizer (wonders if anxiety); Faculative somatasizer (hasn’t thought/ but not opposed; persistant somatasizer; psycholigizer
• Psychosis
• Hypnotic, anxiety, anti conv, coma
• Memory, Anxiety, Insomnia, convulsions
• Buspirone
• ab; a and need gamma
• tolerance to sedation
• Alprazolam
• Triazolam
• Fluzamenil