Drugs Flashcards
Many drugs used in surgical practice are bound to plasma proteins. Which of the following statements is correct?
a) albumin is the plasma protein largely responsible for binding drugs
b) binding is usually irreversible
c) binding to plasma proteins is highly specific, that is, the binding locus is specific for a given drug
d) bound drug has enhanced glomerular filtration
A
Which vitamin helps counteract the deleterious effects of steroids
on wound healing?
Vitamin A
What reverses the effects of protamine? What is the rule of dosing?
Protamine IV (1:100, 1 mg of protamine to every 100 units of heparin)
Who is at risk for a protamine anaphylactic reaction?
Patients with type 1 diabetes mellitus, s/p prostate surgery
Effect of warfarin?
Inhibits vitamin K–dependent clotting factors II, VII, IX, and X, (i.e., 2, 7, 9
and 10 [Think: 2 + 7 = 9 and 10]), produced in the live
How long before surgery should warfarin be discontinued?
From 3 to 5 days preoperatively and IV heparin should be started; heparin should
be discontinued from 4 to 6 hours preoperatively and can be restarted
postoperatively; Coumadin® can be restarted in a few days
How can warfarin cause skin necrosis when first started?
Depressed C and S can result in hypercoagulable state
What is an antibiotic option for colon/appendectomy coverage if the
patient is allergic to penicillin?
IV cipro and IV clinda or IV flagyll
What is the dose of Narcan to reverse the effects of narcotic overdose?
Naloxone 0.4mg IV
What medication reverses the effects of benzodiazepines?
Flumazenil 0.2mg IV
What are the 3 risks of Toradol?
GI Bleed
Renal injury
Platelet dysfunction
What is the treatment for pheochromocytoma?
alpha blocker
Treatment for desmoid tumours?
Tamoxifen
Treatment for bleeding esophageal varices?
Somatostatin
Treatment for diabetes insipidus?
DDAVP
