Drugs

Question 1

List commonly used NSAIDs

• contras
• what to give to PT if cannot take NSAID

Answer 1

Ibuprofen
Indomethacin
Naproxen
TOPICAL: diclofenac gel

CONTRAS

• elderly
• renal insuff
• kindey dz
• piror NSAID sensitivtiy
• allergy
• gastritis
• PUD

ALTERNATIVE= NOT ACETAMINOPHEN if the goal of tx is to prevent inflammation—- YES tylenol for alternative to pain
YES=steroids like prednisone

Question 2

Colchicine

• MOA
• ind

Answer 2

MOA-anti-inflammatory
IND=patients who cannot use NSAIDs or corticosteroids to tx gout, used in acute pseudogout attacks and can be used prophy for pseudogout if PT has 3+ attacks annually
safe in renal injury
**ONLY MED TO BE USED IN ACTUE AND CHRONIC GOUT

Question 3

what is the only med used in acute and chronic gout

Answer 3

colchicine

Question 4

Allopurinol
-moa
-ind
-

Answer 4

MOA: xanthine oxidase inhibition–>causes decr uric acid production
IND: first line prophylaxis for gout— not used during acute attacks
SAFE for renal impairment

Question 5

Probenecid

• moa
• drug class

Answer 5

drug class=uricosuric drugs
MOA=increase urinary uric acid exretion
IND: prophylaxid for gout— not used in acute attack
DO NOT USE IN RENAL INSUFF

Question 6

Alendronate

• moa
• drug class
• inds

Answer 6

Bisphosphonate
*inhibit osteoclast-mediated bone resoprtion and turnover
PO
IND: prevention and management of osteoporosis—- indicated for PT with T-score of -1.5–> -2.5 OR score below -2.5

Question 7

Risedronate

Answer 7

Bisphosphonate
*inhibit osteoclast -mediated bone resoprtion and turnover
PO
IND: prevention and management of osteoporosis—- indicated for PT with T-score of -1.5–> -2.5 OR score below -2.5

Question 8

Denosumab

Answer 8

Monoclonal antibody prevents osteoclasts from developing

*good for high risk PT or PT who failed bisphosphonates

Question 9

Teriparatide

Answer 9

PTH therapy— incrs bone mineral density– SEVERE osteoporosis ( t-score < -3.5)

Question 10

Raloxifene

Answer 10

selecive estrogen receptor modifer–>inhibs bone resoprtion and reduces risk of vertebral fx—- also used for BCA prophylaxis

Question 11

Celecoxib

Answer 11

NSAID

Question 12

Methotrexate

Answer 12

DMARD–disease modyfing antirehyamtic drug

Question 13

Infliximab

Answer 13

DMARD–disease modyfing antirehyamtic drug

***anti-tnf-alpha biologic

Question 14

Tramadol

Answer 14

opioid

Question 15

indomethacin

Answer 15

NSAID

Question 16

Ketorolac

Answer 16

NSAID

Question 17

Naproxen

Answer 17

NSAID

Question 18

cyclobenzaprine HCL

Answer 18

muscle relaxant