Drug Toxicities, HH vs DS, electrolytes Flashcards
Lithium
(Antimania)
Indications: Bipolar disorders - for Manic episodes not for depression
Therapeutic level
Toxic level
Other
Therapeutic level: 0.6 - 1.2
Toxic level: > 2
Other Gray area 1.3 - 2
Lithium
(Antimania)
Therapeutic level: 0.6 - 1.2
Toxic level: > 2
Other Gray area 1.3 - 2
What is it used for
Manic episodes for Bipolar disorder
Lanoxin/ Digoxin
Indications: A-fib, CHF
Therapeutic level:
Toxic level:
Others:
Therapeutic level:1 - 2
Toxic level: >2
Others:
Lanoxin / Digoxin
Therapeutic level:1 - 2
Toxic level: >2
Others:
Indications:
Indications: A-fib & CHF
Aminophylline
(Compound of bronchodilator theophylline)
Indications: Muscle Spasm relaxer for airway
Therapeutic:
Toxic level:
Other:
Therapeutic: 10 - 20
Toxic level: >20
Other: Non-therapeutic level <10 (in this case, increase dose and assess for compliance)
Aminophylline
(Compound of bronchodilator theophylline)
Therapeutic: 10 - 20
Toxic level: >20
Other: Non-therapeutic level <10 (in this case, increase dose and assess for compliance)
Indications;
Indicaciones: Muscle spams relaxer for airway
Dilantin (Phenytoin)
Indication Seizure Medicine
Therapeutic level:
Toxic level:
Therapeutic level: 10 - 20
Toxic level: >20
Dilantin (Phenytoin)
Therapeutic level: 10-20
Toxic level: >20
Indications:
Seizure Medication
Bilirubin
Indication: Breakdown produce of RBC’s
Therapeutic level:
Toxic:
Other:
Therapeutic level: 0.2 - 1.2 for adults, higher for newborns
Toxic: elevated newborn 10 - 20 & Toxic level for newborn is >20
Other: Hospitalize newborns if bili is > 14
Jaundice for excess bilirubin
Pathological: Jaundice within first 24 hrs of birth (concerning/ normal)
Physiological: Jaundice 2 to 3 days postpartum (concerning/ normal)
Pathological: Jaundice within first 24 hrs of birth concerning
Physiological: Jaundice 2 to 3 days postpartum normal
Kernicterus; Excess bilirubin in the brain (bili>20) may cause aseptic/sterile ____ or ______
Meningitis/ Encephalopathy
For Drug Toxicity
Pathological: Jaundice within first 24 hrs of birth (concerning/ normal)
Physiological: Jaundice 2 to 3 days postpartum (concerning/ normal)
Pathological: Jaundice within first 24 hrs of birth concerning
Physiological: Jaundice 2 to 3 days postpartum normal
Toxicity levels
Lithium (Antimania)
Lanoxin/ Digoxin
&
Aminophylline, Dilantin, Bilirubin
Lithium (Antimania)
Lanoxin/ Digoxin
>2
&
Aminophylline, Dilantin, Bilirubin
>20
Opisthotonos…
Hyperextended posistion that the new born assumes d/t irritation of the meninges from kernicterus
A newborn is in the Opisthotonos ( severe backward archingposition) from being kernicterus (bilirubin encephalopathy)
Which position would you put him in
On their side
Hiatal Hernia (does what)
Vs
Dumping Syndrome
regurgitation of acid into the esophagus, upper part of stomach herniates through diaphragm
Right rate but wrong direction
Follows gastric surgery
Gastric contents dump too quickly into duodenum.
Right direction wrong rate
Hatial Hernia S &S
GERD
It is a Haital Herina not just GERD if…
You eat & lay down then get GERD symptoms
Dumping Syndrome S&S
Drunk, Shock, Acute Abdominal Drestress
Drunk
Slurred, staggering, impaired, reaction time, liable
Shock
Hypotension, Tachycardia,
Skin: Pale, Cold, Clammy
Acute Abdominal Distress
Cramping, Pain, Guarding, Diarrhea, Boborigmi
Hiatal Hernia
Interventions
3 things (Elevate Everything)
Elevate HOB 1h post meals
Increase fluid with meals
Increase Carbs / Decrease Protein
(Protein stays in stomach longer)