Drug Therapy for Tuberculosis and mycobacterium avium complex disease

Question 1

primary agents

Answer 1

treat latent, active, and drug-resistant TB infection when possible

Question 2

Isoniazid MOA (PA)

Answer 2

bactericidal antibiotic and nontoxic

Question 3

isoniazid medication administration

Answer 3

PO due to it being well absorbed in the GI tract

Question 4

Adverse effects and Nursing implications for Isoniazid

Answer 4

Hepatoxic, careful with renal impairment; empty stomach and no alcohol

Question 5

Rifamycin (PA) MOA

Answer 5

Bactericidal of intracellular and extracellular TB

Question 6

Rifamycin med admin route

Answer 6

PO since it is well absorbed in GI

Question 7

Patient teaching for Rifamycin

Answer 7

orange discoloration of body secretions
- orange tinge tears, reddish color urine

Question 8

Second line medications

Answer 8

Used for pts who are unable to tolerate first-line drugs; or are infected with first-line resistant bacilli

Question 9

CM of adequate drug therapy for active TB tx

Answer 9

within 2-3 weeks
decreased fever and cough, weight gain, improved well being
tx will continue for six months after

Question 10

Mycobacterium avium Complex

Answer 10

two different types of very similar pathogenic mycobacteria
rarely causes disease in immunocompetent people
found in water and soil throughout the US
transmitted by inhalation of infected water droplets