Drug therapy

Question 1

What is the TYPICAL antipsychotic called?

Answer 1

CHLORPROMAZINE.

Question 2

How can chlorpromazine be taken?

Answer 2

Tablets, syrup, injection.

MAX 1000mg

Question 3

How does chlorpromazine work as an antagonist?

Answer 3

works as an acting ANTAGONIST in the dopamine system. It reduces chemicals which reduce the action of a neurotransmitter, so DOPaMINE antagonist BLOCK dopamine receptors in brain synapse REDUCING action of dopamine.

reduces symptoms like HALLUCINATIONS.

Question 4

How does chlorpromazine work as a sedative?

Answer 4

has an affect on HISTAMINE receptors but not fully understood how this leads to sedation.

Often used to CALM patients not only with sz but other conditions. done when patients are FIRST admitted and very anxious. SYRUP used as absorbed faster.

Question 5

What are the Atypical antipsychotics called?

Answer 5

CLOZAPINE
RISPERIDONE

Question 6

what does clozapine do?

Answer 6

BINDS to dopamine receptors same way chlorpromazine does but also ACTS on serotonin and glutamate receptors. This helps IMPROVE mood and REDUCE depression and anxiety in patients and may IMPROVE cog. functioning.

Often prescribed when patient is at high risk of suicide due to HIGH mood enhancing effects. 30-50% suicide at some point so this is IMPORTANT.

Question 7

why was clozapine dangerous?

Answer 7

DEATH of some patients from a BLOOD condition called Agranulocytosis.

Still used but people tak REGULAR blood tests to ensure they dont develop agran…

NOT available as an INJECTION therefore.

Question 8

What does risperidone do?

Answer 8

Similar to Clozapine WITHOUT serious side-effects. BINDS to dopamine and SEROTONIN receptors, more STRONG as there are SMALLER doses.

Taken as tablets, syrup or injection.