Drug Targets - Cannabis and synthetic canaboids Flashcards
What is the name of the cannabis plant?
Cannabis sativa
What sort of cannabinoids are in cannabis plants?
phyto-cannabindoids
20 carbon ringed structure
What are the endogenous cannabinoids?
listed in order found:
Anandamide
2AG
What is CB1?
A GPCR
What is the drug found in plants that acts on CB1?
THC
What is THC?
THC is an agonist at CB1
What is potency?
The amount of drug required to produce EC50 (50% EMax), more potent = less drug.
What is efficacy?
The largest response able to be produced by the drug
What must be known to measure efficacy?
The signalling pathways
Describe THC at the receptor
THC is a weak (low potency) partial agonist at CB1
Are cannabinoids medicinal cannabis?
No, medicinal cannabis is just the plants. Cannabinoids are the drugs that act on the cannabinoids receptors.
Why should patients not use medicinal cannabis?
No quality control
No doseage
Not regulated as to its processing
How many people have tried cannabis?
50%
What are some suggested theraputic applications of cannabis?
MS
Spinal cord injury (conditions with spasticity)
Epilepsy
Scizophrenia
How do most medicines work?
They work by mimicking the endogenous ligand
How many unique drugs are there?
1357
How many drug targets are there in the humans?
266
What is a cannabis based medicine?
Sativex (nasal spray), contains THC and CBD. Controlled dosage and used for spastic disorders when appropriate.
What has come into play to prevent people from using synthetic cannabinoids?
The psychoactive substances act,
summerized. Drugs must cause no more than low risk harm to users. must be proven.
Are synthetic drugs sold in nz?
No, because they must be proven not to cause harm but people dont want animal testing so.
Plus little known about their safety and effect profile.
