Disease Progress and Drug Action

Question 1

What can clinical pharmacology be described as?

Answer 1

Understanding disease progress and drug action

Question 2

What does drug action refer to?

Answer 2

• Time course of a drug (PKPD)

- link model to account for delays in relation to drug concentration

Question 3

Whats a disease progress model?

Answer 3

Quantitative model that accounts for the time course of a disease status

Disease status = S(t)

Question 4

How may disease status be defined?

Answer 4

Biomarkers
- Signs = physiological or biological measurements of disease activity

Clinical outcomes

• symptoms
• survival

Question 5

What is the simplest disease model?

Answer 5

A linear model (natural history)

S(t) = So + A . t

Question 6

What is the linear + offset (symptomatic) model?

Answer 6

A model that describes the delay in drug action effect and the washout of drug effect once the drug is stopped

Question 7

Whats an example for the linear offset model?

Answer 7

ACh esterase inhibitors for alzhiemers

Question 8

Whats the linear slope disease modifying model?

Answer 8

Accounts for when the disease causes damage / changes that are irreversible when medications are being used i.e the base level of disease changes

Question 9

What are the disease models?

Answer 9

Linear
Linear + offset
Linear + disease modifying