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Pharm Drug Table > Drug Table - Microtubule inhibitors > Flashcards

Drug Table - Microtubule inhibitors Flashcards

1
Q

Microtubule Inhibitors

A

Inhibit mitosis and cause metaphase arrest
by interfering with microtubule function
(tubulin (de)polymerization); CCS

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2
Q

Vinblastine (Velban) Class

A

Vinca alkaloids

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3
Q

Vinblastine (Velban) Mech

A

Block tubulin polymerization into

microtubules

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4
Q

Vinblastine (Velban) Therapeutics

A

Metastatic testicular tumors (with
bleomycin, cisplatin); component of
ABVD used for Hodgkin’s disease

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5
Q

Vinblastine (Velban) Other side effects

A

Myelosuppression, nausea,

vomiting

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6
Q

Vincristine (Oncovin) Class

A

Vinca alkaloids

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7
Q

Vincristine (Oncovin) Mech

A

Block tubulin polymerization into

microtubules

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8
Q

Vincristine (Oncovin) Therapeutics

A

Childhood ALL (with glucocorticoids);
Hodgkin’s and non-Hodgkin’s
lymphomas

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9
Q

Vincristine (Oncovin) Important side effects

A

Dose-limiting neurotoxicity

peripheral neuropathy

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10
Q

Vincristine (Oncovin) Other side effects

A

Relatively low bone marrow

toxicity

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11
Q

Paclitaxel (Taxol, Abraxane) Class

A

Taxanes

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12
Q

Paclitaxel (Taxol, Abraxane) Mech

A

Block microtubule depolymerization into

tubulin

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13
Q

Paclitaxel (Taxol, Abraxane) Therapeutics

A

Metastatic breast, ovarian, lung, and

head and neck cancers

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14
Q

Paclitaxel (Taxol, Abraxane) Imp side effects

A

Peripheral neuropathy

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15
Q

Paclitaxel (Taxol, Abraxane) other side effects

A

Neutropenia; hypersensitivity

reactions

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16
Q

Docetaxel (Taxotere) class

A

Taxanes

17
Q

Docetaxel (Taxotere) Mech

A

Block microtubule depolymerization into

tubulin

18
Q

Docetaxel (Taxotere) Therapeutics

A

Metastatic breast, ovarian, lung, and
head and neck cancers; hormone
refractory prostate cancer

19
Q

Docetaxel (Taxotere) Important side effects

A

Peripheral neuropathy

20
Q

Docetaxel (Taxotere) Other side effects

A

Neutropenia; hypersensitivity

reactions

Pharm Drug Table (11 decks)

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