Drug Side-Effects/Interactions

Question 1

Photosensitivity drugs

Answer 1

SAT: Sulfonamides, Amiodarone, Tetracyclines

Question 2

Grey baby syndrome, Grey man syndrome, Red man syndrome?

Answer 2

Chloramphenicol; Amiodarone; Vancomycin

Question 3

What drugs should a patient with a Sulfa allergy avoid?

Answer 3

PFACTSSS: Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide abx, Sulfasalazine, Sulfonylureas

Question 4

What drugs cause a disulfiram-like rxn?

Answer 4

Disulfiram (antabuse), certain Cephalosporins, Metronidazole, 1st gen Sulfonylureas, Procarbazine

Question 5

Drug-induced Lupus

Answer 5

SHIPP: Sulfonamides, Hydralazine, INH, Procainamide, Pheytoin (dX with anti-Histone antibodies)

Question 6

Drugs that induce P450

Answer 6

BCG PQRS: Barbiturates, Carbamazepine, Griseofulvin, Phenytoin, Quinidine, Rifampin, St. John’s Wart

Question 7

Drugs that inhibit P450

Answer 7

PICK EGS: Protease inhibitors, INH, Cemitidine, Ketoconazole, Erythromycin, Grapefruit Juice, Sulfonamides

Question 8

Drugs with anti-muscarinic effects:

Answer 8

• Atropine
• TCAs (e.g., amitriptyline)
• H1 receptor antagonists (e.g., diphenhydramine)
• Neuroleptics
• Antiparkinsonian drugs

Question 9

Drugs that cause coronary vasospasm

Answer 9

Sumatriptan, ergot alkaloids, cocaine, amphetamines

Question 10

Drugs that cause cutaneous flushing

Answer 10

VANC: Vancomycin, Adenosine, Niacin, CCBs

Question 11

Drugs that cause dilated cardiomyopathy

Answer 11

Doxorubicin, Duanorubicin

Question 12

Drugs that cause torsades de pointes

Answer 12

Class IA (quinidine) and Class III (sotalol) antiarrhythmics, Macrolides, Haloperidol, Risperidone, Antimalarials, Methadone, Protease Inhibitors
*Tx with Magnesium sulfate

Question 13

Drugs that cause agranulocytosis

Answer 13

Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone

Question 14

Drugs that cause aplastic anemia

Answer 14

Chloramphenicol, Benzene, NSAIDs, Propylthiouracil, Methimazole

Question 15

Drugs that cause direct coombs-positive hemolytic anemia

Answer 15

Methyldopa, Penicillin

Question 16

Drugs that cause gray baby syndrome

Answer 16

Chloramphenicol

Question 17

Drugs that cause hemolysis in G6PD deficient patients

Answer 17

“Hemolysis IS PAIN”

*Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin; also Dapsone, Napthelene, Fava beans

Question 18

Drugs that cause megaloblastic anemia

Answer 18

“Having a blast with PMS”

*Phenytoin, Methotrexate, Sulfa drugs

Question 19

Drugs that cause thrombotic complications (DVT, PE)

Answer 19

OCPs, especially in smokers, >35, migraine with aura

Question 20

Drugs that cause thrombocytopenia

Answer 20

Heparin, H2 blockers

Question 21

Drugs that cause cough

Answer 21

ACE-Is

Question 22

Drugs that cause pulmonary fibrosis

Answer 22

Bleomycin, Amiodarone, Bisulfan

Question 23

Drugs that cause acute cholestatic hepatitis and jaundice

Answer 23

Erythromycin (though macrolides are generally safe in pregnancy)

Question 24

Drugs that cause focal to massive hepatic necrosis

Answer 24

“Liver HAVAc”

*Halothane, Amanita phalloides (alpha-amanitin inhibits RNA polymerase II, causing hepatotoxicity), Valproic acid, Acetaminophen

Question 25

Drugs that cause hepatitis

Answer 25

INH

Question 26

Drugs that cause pseudomembranous colitis

Answer 26

Clindamycin, ampicillin, all abx

Question 27

Drugs that cause adrenal insufficiency (tertiary)

Answer 27

Glucocorticoid withdrawal (HPA suppression)

Question 28

Drugs that cause gynecomastia

Answer 28

"Some Drugs Create Awkward Knockers" | *Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, Ketoconazole; also Marijuana

Question 29

Drugs that cause hot flashes

Answer 29

Tamoxifen, Clomiphene

Question 30

Drugs that cause hyperglycemia

Answer 30

Niacin, Tacrolimus, Protease inhibitors, HCTZ, Corticosteroids

Question 31

Drugs that cause hypothyroidism

Answer 31

Lithium, Amiodarone, Sulfonamides

Question 32

Drugs that cause fat redistribution

Answer 32

Glucocorticoids, Protease inhibitors

Question 33

Drugs that cause gingival hyperplasia

Answer 33

Phenytoin, Verapamil

Question 34

Drugs that cause gout

Answer 34

Furosemide, Thiazides, Niacin, Cyclosporine

Question 35

Drugs that cause myopathies

Answer 35

"Fish N CHIPS Give you myopathies" | *Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-alpha, Penicillamine, Statins, Glucocorticoids

Question 36

Drugs that cause osteoporosis

Answer 36

Corticosteroids, heparin

Question 37

Drugs that cause rash (Stevens-Johnsons syndrome)

Answer 37

"Bad rash after a PEC SLAPP" *Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital (Seizures, Sulfas, -Cillins)

Question 38

Drugs that cause photosensitivity

Answer 38

"SAT for a photo" | *Sulfonamides, Amiodarone, Tetracycline

Question 39

Drugs that cause SLE-like syndrome

Answer 39

SHIPP | *Sulfonamide, Hydralazine, INH, Procainamide, Phenytoin

Question 40

Drugs that affect teeth (kids)

Answer 40

Tetracylines

Question 41

Drugs that cause diabetes insipidus

Answer 41

Lithium, Demeclocycline | *Tx with Hydrochlorothiazide (plus Ameloride for Lithium-induced NDI)

Question 42

Drugs that cause Fanconi's syndrome

Answer 42

*Defective PCT reabsorption: | Expired tetracycline, heavy metal exposure, Wilson's disease

Question 43

Drugs that cause tendonitis, tendon rupture, cartilage damage

Answer 43

Fluoroquinolones

Question 44

Drugs that cause hemorrhagic cystitis

Answer 44

Cyclophosphamide, ifosfamide (prevent by coadministering with Mesna)

Question 45

Drugs that cause interstitial nephritis

Answer 45

Methicillin, NSAIDs, Furosemide

Question 46

Drugs that cause SIADH

Answer 46

Carbamazepine, Cyclophosphamide

Question 47

Drugs that cause Parkinson-like syndrome

Answer 47

Antipsychotics, Reserpine, Metoclopramide, MPTP (toxic metabolite of illegal demerol production)

Question 48

Drugs that cause seizures

Answer 48

"With seizures, I BITE My tongue" * INH, Buproprion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide * Also, evening primrose oil and BZD/EtOH withdrawal

Question 49

Drugs that cause cinchonism

Answer 49

Quinidine, quinine

Question 50

Drugs that cause tardive dyskinesia

Answer 50

Antipsychotics

Question 51

Drugs that cause disulfiram reaction

Answer 51

Metronidazole, certain Cephalosporins, Procarbazine, 1st generation Sulfonylureas, Disulfiram

Question 52

Drugs that cause antimuscarinic symptoms

Answer 52

Atropine, TCAs, H1 blockers, Neuroleptics

Question 53

Drugs that cause nephrotoxicity/ototoxicity

Answer 53

Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin