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Drug Side-Effects/Interactions Flashcards

1
Q

Photosensitivity drugs

A

SAT: Sulfonamides, Amiodarone, Tetracyclines

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2
Q

Grey baby syndrome, Grey man syndrome, Red man syndrome?

A

Chloramphenicol; Amiodarone; Vancomycin

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3
Q

What drugs should a patient with a Sulfa allergy avoid?

A

PFACTSSS: Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide abx, Sulfasalazine, Sulfonylureas

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4
Q

What drugs cause a disulfiram-like rxn?

A

Disulfiram (antabuse), certain Cephalosporins, Metronidazole, 1st gen Sulfonylureas, Procarbazine

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5
Q

Drug-induced Lupus

A

SHIPP: Sulfonamides, Hydralazine, INH, Procainamide, Pheytoin (dX with anti-Histone antibodies)

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6
Q

Drugs that induce P450

A

BCG PQRS: Barbiturates, Carbamazepine, Griseofulvin, Phenytoin, Quinidine, Rifampin, St. John’s Wart

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7
Q

Drugs that inhibit P450

A

PICK EGS: Protease inhibitors, INH, Cemitidine, Ketoconazole, Erythromycin, Grapefruit Juice, Sulfonamides

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8
Q

Drugs with anti-muscarinic effects:

A
  • Atropine
  • TCAs (e.g., amitriptyline)
  • H1 receptor antagonists (e.g., diphenhydramine)
  • Neuroleptics
  • Antiparkinsonian drugs
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9
Q

Drugs that cause coronary vasospasm

A

Sumatriptan, ergot alkaloids, cocaine, amphetamines

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10
Q

Drugs that cause cutaneous flushing

A

VANC: Vancomycin, Adenosine, Niacin, CCBs

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11
Q

Drugs that cause dilated cardiomyopathy

A

Doxorubicin, Duanorubicin

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12
Q

Drugs that cause torsades de pointes

A 
Class IA (quinidine) and Class III (sotalol) antiarrhythmics, Macrolides, Haloperidol, Risperidone, Antimalarials, Methadone, Protease Inhibitors
*Tx with Magnesium sulfate
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13
Q

Drugs that cause agranulocytosis

A

Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone

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14
Q

Drugs that cause aplastic anemia

A

Chloramphenicol, Benzene, NSAIDs, Propylthiouracil, Methimazole

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15
Q

Drugs that cause direct coombs-positive hemolytic anemia

A

Methyldopa, Penicillin

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16
Q

Drugs that cause gray baby syndrome

A

Chloramphenicol

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17
Q

Drugs that cause hemolysis in G6PD deficient patients

A

“Hemolysis IS PAIN”

*Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin; also Dapsone, Napthelene, Fava beans

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18
Q

Drugs that cause megaloblastic anemia

A

“Having a blast with PMS”

*Phenytoin, Methotrexate, Sulfa drugs

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19
Q

Drugs that cause thrombotic complications (DVT, PE)

A

OCPs, especially in smokers, >35, migraine with aura

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20
Q

Drugs that cause thrombocytopenia

A

Heparin, H2 blockers

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21
Q

Drugs that cause cough

A

ACE-Is

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22
Q

Drugs that cause pulmonary fibrosis

A

Bleomycin, Amiodarone, Bisulfan

23
Q

Drugs that cause acute cholestatic hepatitis and jaundice

A

Erythromycin (though macrolides are generally safe in pregnancy)

24
Q

Drugs that cause focal to massive hepatic necrosis

A

“Liver HAVAc”

*Halothane, Amanita phalloides (alpha-amanitin inhibits RNA polymerase II, causing hepatotoxicity), Valproic acid, Acetaminophen

25
Q

Drugs that cause hepatitis

26
Q

Drugs that cause pseudomembranous colitis

A

Clindamycin, ampicillin, all abx

27
Q

Drugs that cause adrenal insufficiency (tertiary)

A

Glucocorticoid withdrawal (HPA suppression)

28
Q

Drugs that cause gynecomastia

A

“Some Drugs Create Awkward Knockers”

*Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, Ketoconazole; also Marijuana

29
Q

Drugs that cause hot flashes

A

Tamoxifen, Clomiphene

30
Q

Drugs that cause hyperglycemia

A

Niacin, Tacrolimus, Protease inhibitors, HCTZ, Corticosteroids

31
Q

Drugs that cause hypothyroidism

A

Lithium, Amiodarone, Sulfonamides

32
Q

Drugs that cause fat redistribution

A

Glucocorticoids, Protease inhibitors

33
Q

Drugs that cause gingival hyperplasia

A

Phenytoin, Verapamil

34
Q

Drugs that cause gout

A

Furosemide, Thiazides, Niacin, Cyclosporine

35
Q

Drugs that cause myopathies

A

“Fish N CHIPS Give you myopathies”

*Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-alpha, Penicillamine, Statins, Glucocorticoids

36
Q

Drugs that cause osteoporosis

A

Corticosteroids, heparin

37
Q

Drugs that cause rash (Stevens-Johnsons syndrome)

A

“Bad rash after a PEC SLAPP”
*Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital
(Seizures, Sulfas, -Cillins)

38
Q

Drugs that cause photosensitivity

A

“SAT for a photo”

*Sulfonamides, Amiodarone, Tetracycline

39
Q

Drugs that cause SLE-like syndrome

A

SHIPP

*Sulfonamide, Hydralazine, INH, Procainamide, Phenytoin

40
Q

Drugs that affect teeth (kids)

A

Tetracylines

41
Q

Drugs that cause diabetes insipidus

A

Lithium, Demeclocycline

*Tx with Hydrochlorothiazide (plus Ameloride for Lithium-induced NDI)

42
Q

Drugs that cause Fanconi’s syndrome

A

*Defective PCT reabsorption:

Expired tetracycline, heavy metal exposure, Wilson’s disease

43
Q

Drugs that cause tendonitis, tendon rupture, cartilage damage

A

Fluoroquinolones

44
Q

Drugs that cause hemorrhagic cystitis

A

Cyclophosphamide, ifosfamide (prevent by coadministering with Mesna)

45
Q

Drugs that cause interstitial nephritis

A

Methicillin, NSAIDs, Furosemide

46
Q

Drugs that cause SIADH

A

Carbamazepine, Cyclophosphamide

47
Q

Drugs that cause Parkinson-like syndrome

A

Antipsychotics, Reserpine, Metoclopramide, MPTP (toxic metabolite of illegal demerol production)

48
Q

Drugs that cause seizures

A

“With seizures, I BITE My tongue”

  • INH, Buproprion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
  • Also, evening primrose oil and BZD/EtOH withdrawal
49
Q

Drugs that cause cinchonism

A

Quinidine, quinine

50
Q

Drugs that cause tardive dyskinesia

A

Antipsychotics

51
Q

Drugs that cause disulfiram reaction

A

Metronidazole, certain Cephalosporins, Procarbazine, 1st generation Sulfonylureas, Disulfiram

52
Q

Drugs that cause antimuscarinic symptoms

A

Atropine, TCAs, H1 blockers, Neuroleptics

53
Q

Drugs that cause nephrotoxicity/ototoxicity

A

Aminoglycosides, Vancomycin, Loop diuretics, Cisplatin

Pharm (7 decks)

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