Neuroleptics

Question 1

High Potency Neuroleptics

Answer 1

Try to Fly High: Trifluoperazine, Fluphenazine, Haloperidol

Potent = EPS symptoms

Question 2

Low Potency Neuroleptics

Answer 2

Cheating Thieves are Low: Chlopromazine, Thioridazine

Low potency = Anticholinergic SE

Question 3

Neuroleptic Malignant Syndrome

Answer 3

Muscle rigidity…

Question 4

Drugs that worsen mental status (avoid in demented patients)

Answer 4

Diphenhydramine, Benzodiazepine…

Instead, give Trazodone or Haloperidol (high potency neuroleptic, not low!)

Question 5

Mania

Answer 5

DIG FAST

Question 6

Depression

Answer 6

SIGE CAPS

Question 7

Milder bipolar disorder

Answer 7

Cyclothymia: Manic or Hypomanic episodes + Dysthymia

Question 8

Bipolar Disorder tx

Answer 8

Mood stablizers: Lithium, Valproate, Carbamazepine, Atypical antipsychotics (Olanzapine, Aripiprazole)

Question 9

Lithium Side Effects

Answer 9

MNOP: Movement (tremor), NDI and polyuria, hypOthyroidism, Pregnancy problems (Ebstein’s anomaly)

Question 10

MDE criteria

Answer 10

≥2 weeks of ≥5 symptoms of SIGE CAPS, including depression/anhedonia

Question 11

Atypical depression

Answer 11

Increased appetite, sleep; mood reactivity, sensitive to rejection, psychomotor retardation (lead paralysis)
Tx: MAOI or SSRI (No TCA!)

Question 12

Milder depression

Answer 12

Dysthymia: ≥2 years of 2 SIGE CAPS symptoms

Question 13

Suicide risk

Answer 13

SAD PERSONS (*Organized plan)

Question 14

Typical vs. Atypical Neuroleptics

Answer 14

Typicals: block D2 receptor
Atypicals: block D2 + 5HT receptors