Drug review

Question 1

Benzodiazepine side effects

Answer 1

Drowsiness and confusion
Ataxia (lack of certain muscle control)
Driving motor vehicles
Cognitive impairment
- decreased long term recall
- decreased recall
Use cautiously with liver disease

Question 2

Cyclobenzaprine indications and MOA

Answer 2

Brand name flexeril.
Muscle relaxer
Fibromyalgia
MOA: skeletal muscle relaxant, acts primarily at the brain stem

Question 3

Cymbalta, common name, MOA, indications

Answer 3

Duloxetine HCL
Selective serotonin and norepinephrine reuptake inhibitor
1. Depression
2. Diabetic peripheral neuropathic pain
3. Fibromyalgia
4. Generalized anxiety disorder
5. Chronic musculoskeletal pain

Question 4

Fluoxetine HCl, indications and MOA

Answer 4

Bulimia nervoas
Depressed bipolar
Major depressive disorder
Obsessive-compulsive disorder
Panic disorder
Premenstral dysphoric disorder
MOA: SSRI

Question 5

Sertraline

Answer 5

AKA: zoloft
SSRI
Indications: Binge-eating disorder, bulimia nervosa, generalized anxiety disorder

Question 6

Chlorthalidone

Answer 6

Sulfonamide-derived diuretic
Indicated: Edema and HTN
Warnings: Electrolyte disturbances, hx of gout can preciipitate, Sulfa allergy, photosensitivity
Rx for HTN: 12.5-25mg once a day may increase to 50mg once a day

Question 7

Aspirin: Indications, MOA, CI, AE, dosing…

Answer 7

MOA: Irreversibly Inhibits COX 1 and COX 2, inhibits platelet aggregation, antipyretic, analgesic, anti-inflammatory.
Indications: mild-moderate pain, inflammation, fever, prevention of acute coronary symptoms, management of RA
AE: Hemorrhage, GI ulcer
Dose: 325-650 every 4-6 hours, up to 4 grams per day

Question 8

Naproxen: Indications, MOA, CI, AE, dosing…

Answer 8

Reversibly inhibits COX 1 and COX 2, antipyretic, anti-inflam, analgesic
Indications: gout, RA, bursitis, tendonitis
AE: heartburn, abdominal pain, n/v/d, tinnitus, dizziness, rash, HA
Dosing: 200 mg every 8-12 hours, can use 400 mg base dose. Max 600 mg in 24hours

Question 9

Ibuprofen dosing

Answer 9

OTC: 200 mg every 4-6 hours PRN
Max: 1200 mg per day except with OA or RA: 3200 mg per day max but not for longer than 10 days

Question 10

celecoxib (Celebrex): MOA, indications, CI, AE, dosing

Answer 10

MOA: inhibits COX 2, antipyretic, analgesic, anti-inflam
Indications: Acute pain, RA, OA, primary dysmenorrhea, ankylosing spondylitis
AE: NSAID standard plus peripheral edema and cough
Dosing: initial: 400 mg, then after 200 mg BID

Question 11

indomethacin (Indocin)

Answer 11

MOA: Reversibly inhibits COX 1 and COX 2, antipyretic, anti-inflam, analgesic
Indications: pain, arthritis, inflammatory conditions, patent ductus arteriosus
Dosing: 20 TID, or 40 mg 2-3 times per day

Question 12

meloxicam (Mobic)

Answer 12

MOA: Reversibly inhibits COX 1 and COX 2, antipyretic, anti-inflam, analgesic
Indications: OA, RA, juvRA
AE: URI, UTI, dyspepsia, edema, arthralgia
Dosing: 7.5 mg QD to 15mg QD, Max: 15mg daily

Question 13

ketorolac (Toradol)

Answer 13

MOA: Reversibly inhibits COX 1 and COX 2, antipyretic, anti-inflam, analgesic
Indication: short term management (less than or equal to 5 days) for moderate to severe pain
AE: NSAID standards drowsiness, edema
Dosing: Usually start with IV or IM and goes to oral. Max parenteral 120mg per day, oral 40 mg per day.

Question 14

Clonidine uses and MOA

Answer 14

MOA: Stimulates alpha2-adrenoceptors in the brain stem
Indications: Hypertension, ADHD,…