Drug Receptor Concepts 1 Flashcards
What are the primary events of pain relief?
1- Administration and absorption of the drug into the body
2- Distribution of the drug throughout the body
3- Interaction of the drug with relevant functional components of the body
4- The elimination of the drug from the body
What is Pharmacology?
The study of the interaction between drugs and the living body
What is Pharmacodynamics?
The study of the effects of drugs on the living body and how the effects are produced?
What is pharmacokinetics?
The study of how the body deals with or handles drugs
What is pharmacotherapeutics?
The study of the use of drugs in the treatment & prevention of disease
What are the two types of drug action?
Non-specific drug action
Specific drug action
What is Non-specific drug action?
- acts in a simple physical or chemical manner
- Lack any specific structure-activity relationship
- Require large doses of drug for effect
What is specific drug action?
- act in a specific manner
- Interact with or bind to specific macromolecules or cellular targets in the body, called receptors
- Shows structure-activity relationship
- Produce Biological effects at very low doses
What is the Drug Receptor Concept?
Drugs produce their biological effects by interacting with specific macromolecules in the body called receptors
What is a Receptor?
A specialised component of the cell or organism that interacts with a drug and initiates the chain of biochemical events leading to the drugs observed biological effects
What are drug receptors?
They are proteins and glycoprotein molecules
Where are drug receptors located?
Located on the cell membrane
What is a classical receptor?
A regulatory protein or binding sites for endogenous or natural chemical messengers such as neurotransmitters & hormones
Why does a drug bind to receptors?
The drugs molecular structure & shape are similar to those of the natural chemical messengers the body produces to target those receptors
What must there be for a drug to bind to the receptor?
There must be a fit complementary between the drug and the binding site of the receptor
