Drug reactions 2 Flashcards
MSK: fat redistribution
Glucocorticoid
Protease inhibitors
MSK: gingivial hyperplasia
Phenytoin
Verapamil
Cyclosporin
MSK: gout
Furosemide
Thiazide,
Niacin
Cyclosporine
MSK: myopathies
Fibrates Niacin Colchicine Hydroxychloroquine Interferon alpha Penicillamine Statins Glucocorticoid
“Fish N CHIPS Give you myopathies”
MSK: Osteoporosis
Corticosteroids
Heparin
MSK: Photosensitivity
Sulfonamide
Amidoraone
Tetracycline
“SAT for a photo”
MSK: Rash (SJS)
Penicillin Ethosuximide Carbapazepine, Sulfa drugs Lamotrigine Allopurinol Phenytoin Phenobarbital
“Bad rash after a PEC SLAPP”
MSK: SLE like syndrome
Hydralazine
INH
Procainamide
Phenytoin
“It is not HIPP to have lupus”
MSK: tendonitis, rupture, and cartilage damage
Fluoroquinolone
Renal: diabetes insipidus
Lithium
Demeclocycline
Renal: falconi’s syndrome
Expired tetracyclin
Renal: hemorrhagic cystitis
Cyclophoshamide
Ifosfamide (prevented by coadministering with mesna)
Renal: interstitial nephritis
Methicillin
NSAIDS
Furosemides
Renal: SIADH
Carbamazapine
Cyclophosphamide
Neuro: cinchonism
“cinchonism: due to too much quinine, flushed and sweaty skin, ringing of the ears (tinnitus), blurred vision, impaired hearing, confusion, reversible high-frequency hearing loss, headache, abdominal pain, rashes, drug-induced lichenoid reaction (lichenoid photosensitivity),[1] vertigo, dizziness, dysphoria, nausea, vomiting and diarrhea.”
Quinidine
Quinine
Neuro: Parkinson like syndrome
Antipsychotic
Reserpine
Metoclopramide
Neuro: seizures
INH Bupropion Imipenem/cilastatin, Tramadol Enfurane Metoclopramide
“With seizures, I BITE My tongue”
Neuro: Tardive dyskinesia
Antipsychotics
Multiorgan: antimuscarinic
Atropine
TCA,
H1 blockers
Neuroleptics
Multiorgan: disulfram like reaction
Metronidazole
Certain cephalosporins
Procabazine
1st generation sulfonylureas
Multiorgan: nephrotoxic and ototoxic
Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin
P450 inducers
Modafinil Barbiturates St Johns' wort Phentyoin Rifampin Griseofulvin Carbamazepine Chronic alcohol use
“Momma Barb Steals Phen-phen and Refuses Greasy Carb Chronically”
P450 inhibitors
Macrolides Amiodarone Grapefruit juice INH Cimetidine Ritonavir Acute alcohol abuse Cipro Ketoconazole Sulfonamides Gemfibrozil Quinidine
“MAGIC RACKS in GQ”
Sulfa drugs
Probenecid Furosemide Acetazolamide Celecoxib Thiazides Sulfonamide Abx Sulfasalazine Sulfonylureas
If allergic, develop fever, UTI, pruritic rash, SJS, hemolytic anemia, thrombocytopenia, agranulocytosis, and hives.
“Popular FACTSSS”
Things that end in…
- Triptan: 5-HT1B/1D agonist
- Operidol: butyrophenone; neuroleptic; haloperidol
- azine: phenothiazine; neuroleptic, antiemetic; chlorpromazine
- ipramine: TCA; imipramine
- triptyline: TCA; amitriptyline
- etine: SSRI: fluoxetine
- pril: ACEi vs. -arb: ACE receptor blocker
