adrenergic blockers Flashcards
Phenoxybenzamine
Nonselective alpha blocker, IRREVERSIBLE
USE: pheo before removing tumor
Toxicity: orthostatic hypotension, reflex tachy
Phenolamine
Nonselective alpha blocker, REVERSIBLE
Give to patients on MAO inhibitor who contain tyramine containing food (as tyramine acts as catecholamine releasing agents)
Prazosin, terazosin, doxazosin, tamsulosin
Alpha 1 selective
Use: HTN, urinary retention in BPH
Toxicity: 1st dose orthostatic hypotension, dizziness, HA
Mirtazapine
Alpha 2 selective
Use: depression
Toxicity: sedation, increased serum cholesterol, increased appetite.
Alpha blockage of EP and phenylephrine
The effect of alpha blocker (phentolamine) on BP to EP and phenylephrine
EP: reversal of mean blood pressure change, from anet increase (the alpha response) to a net decrease (beta response)
Phenyl: no repsonse as it is purely alpha.
Beta blocker: uses
USES
Angina: decrease HR and contractility, low O2 consumption
MI: decreases mortality
SVT: metoprolol and esmolol: decreases AV conduction velocity, Class II antiarrhythmic
HTN: decrease cardiac output, decrease renin secretion (due to beta1 blockage on JCA cells)
CHF: slow progression of chronic failure
Glaucoma: timolol: decrease secretion of aqueous humor (timolol=tear)
Beta blocker: toxicity
Toxicity: impotence, asthma, CV (bradycardia, AV block, CHF), CNS adverse effects (seizures, sedation, sleep alteration); use with caution with diabetic
Beta blocker: B1 selective
B1 selective: acetutolol (partial agonist), betaxolol, esmolol (short acting), atenolol, metoprolol
“A BEAM of b1 blockers: good for pts with pulm dz”
Beta blocker: non selective (B1=B2)
Nonselective: propanolol, timolol, nadolol, pindolol
“Please Try Not Being Picky”
Beta blocker: alpha and beta antagonists
Nonselective (vasodilatory) alpha and beta antagonists
Carvediol, labetalol
Beta blocker: partial agonists
Partial beta agonists: Pindolol and Acebutolol
“PAPA”
