Drug Pharmacology

Question 1

What are the 4 main types of drug target?

Answer 1

• Receptors
• Enzymes
• Carrier molecules
• Ion channels

Question 2

What is a receptor?

Answer 2

• A protein that binds to neurotransmitter/ modulator
• A target molecule which soluble physiological mediators produce their effect

Question 3

What are the main receptor classes?

Answer 3

• Ligand gated ion channels
• G protein coupled receptors
• Enzyme linked receptors
• Intracellular receptors

Question 4

What are the 3 receptor bonding experiments?

Answer 4

• Kinetic : how the response changes with time
• Saturation: binding with increasing concentrations of ligand
• Competition/ modulation : binding of 1/ more fixed concs of ligand with different concs of other drug. Compete for same bonding site

Question 5

What is an agonist?

Answer 5

• A substance that interacts with specific cellular