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Drug of Abuse Flashcards

1
Q

Physical
Tolerance
Withdrawal Syndrome
Non psychoactive drugs

A

Dependence

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2
Q

Psychological
Compulsion
Relapsing
Craving

A

Addiction

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3
Q

High potential for abuse, no known medical use and lacks accepted safety for use
E.g Heroin, Lysergic acid diethylamide

A

Schedule I

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4
Q

Potential for abuse with proven and accepted medical use but WITH SEVERE RESTRICTIONS, because abuse may cause severe psycho/physio dependence
E.g morphine, cocaine, methadone, methampetamine, phencyclidine

A

Schedule II

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5
Q
  • Less potential for abuse than schedule I or II; with accepted medical use
  • Abuse may cause moderate or low physical dependence or high psychological dependence
  • Anabolic steroids, codeine and hydrocodone, with aspirin or Tylenol
A

Schedule III

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6
Q
  • The drug or other substance has a low potential for abuse relative to the drugs or other substances in Schedule III
  • Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in Schedule III
  • Valium and Xanax
A

Schedule IV

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7
Q
  • The drug or other substance has a low potential for abuse relative to the drugs or other substances in Schedule IV
  • Cough syrups and codeine
A

Schedule V

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8
Q

Reduction of concentration
Shorter duration of action

A

Pharmacokinetic Tolerance

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9
Q

Recruitment of Adaptor protein (β arrestin)
Desensitization
Receptor internalization

A

Pharmacodynamic Tolerance

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10
Q

Alter perception; no reward/euphoria
targets cortical and thalamic system

A

Nonaddictive Drug of Abuse

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11
Q

Hallucinogens
Dissociative anesthetics
LSD
PCP/Ketamine
Dextromethorphan

A

Nonaddictive Drug of Abuse

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12
Q

receptors of:
Opioids, Cannabinoids, GHB, LSD, Mescaline & Psilocybin

A

G protein coupled

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13
Q

receptors of:
Nicotine, Benzodiazepines, Alcohol, Ketamine & PCP Inhalants

A

Ionotropic receptors

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14
Q

receptors of:
Cocaine, Amphetamines, Ecstasy(MDMA)

A

Biogenic Amines

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15
Q

Strong analgesics

A

Opioids

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16
Q

morphine, codeine, thebaine, papaverine

A

Opiates

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17
Q

“sleep inducing”

A

Narcotic

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18
Q

affinity of mu

A

endorphins>enkephalins>dynorphins

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19
Q

affinity of delta

A

enkephalins>endorphins>dynorphins

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20
Q

affinity of kappa

A

dynorphins> endorphins and enkephalins

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21
Q

Papaver somniferum

A

Opium

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22
Q
  • powerful narcotic, painkiller
  • principal active ingredient is MORPHINE
A

Opioids

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23
Q

diamorphine

A

Heroin

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24
Q

an addictive drug as a white or brown powder

A

Heroin

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25
half life of heroine
T1/2= 3 5 hrs, therefore several doses/ day
26
oxycodone is synthesized from
thebaine
27
oxycodone is derived from
codeine
28
serious interaction with MAO’s
Meperidine
29
attempts to illicitly produce meperidine has resulted in MPTP which can cause
parkinsonism
30
increased CNS depression, particularly respiratory depression
sedative-hypnotics
31
increased sedation. variable effects on respiratory depression. accentuation of cardiovascular effects
antipsychotic agents
32
relative contradiction to all opioid analgesics because of the high incidence of hyperpyrexic coma
monoamine oxidase inhibitors
33
alcohol, barbiturates, benzodiazepines, gamma hydroxybutyric acid (GHB)
Sedative - hypnotics
34
true or false: in sedatives, the longer the duration the less the withdrawal
true
35
rare occurrence of physiologic dependence
Benzodiazepines
36
weight loss, change in perception, paresthesia, headache
“Therapeutic Dose Dependence"
37
used for date rape
Flunitrazepam (Rohypnol)
38
causes anterograde amnesia
Flunitrazepam (Rohypnol)
39
- GABAa receptors - usually Short acting drugs - eg. Secobarbital, pentobarbital Na
Barbiturates
40
withdrawal effects: motor agitation, anxiety, insomnia, hallucination, abnormal vital signs, seizures
Alcohol
41
- GABAb - naturally found in body - can be found in fermented drinks like guava (Psidium guajava) - liquid ecstasy, soap, easy lay, vita G - Georgia homeboy
Gamma Hydroxybutyric Acid
42
withdrawal effects include: insomnia, anxiety, tremors, sweating
Gamma Hydroxybutyric Acid
43
use with alcohol can produce breathing problems
Gamma Hydroxybutyric Acid
44
treatment for for Short acting and Long acting drugs
chlordiazepoxide or phenobarbital
45
treatment for alcohol
disulfiram, naltrexone
46
Cannabis sativa
Marijuana
47
cannabinol, tetrahydrocannabinol , cannabidiol
Cannabinoids
48
- antiemetic - tolerance - uncertain effect on fetus - Amotivational syndrome - diseases related to smoking
Cannabinoids
49
substances that cause hallucinations
Hallucinogens
50
LSD, PCP, Ketamine, Scopolamine are examples of what substance?
Hallucinogens
51
synthetic agent related to ergot alkaloids
LSD
52
NE, dopamine, serotonin
LSD
53
5 HT1a & 5 HT1c agonists
LSD
54
rise in body temp Hallucinations uterine contractions elevated sugar levels goosebumps Euphoria pupil dilation are effects of what substance?
LSD
55
Psilocybe mushroom
Psilocybin
56
mydriasis, muscle relaxation, dizziness are effects of what substance?
Psilocybin
57
- anesthetic -“special K” “vitamin dream like states, hallucination, delirium, amnesia, high BP, depression, fatal respiratory problems
Ketamine
58
phenylcyclohexamine deriv.
Phencyclidine (angel dust, PCP)
59
veterinary anesthetic
Phencyclidine (angel dust, PCP)
60
antagonize NMDA
Phencyclidine (angel dust, PCP)
61
users tend to be violent and suicidal
Phencyclidine (angel dust, PCP)
62
block central muscarinic receptors
Scopolamine
63
dopaminergic reuptake transmitter
Cocaine
64
inhibit reuptake of dopamine and NE
Cocaine
65
half life of cocaine
t1/2= 1hr, repeated 30min
66
symptoms include a feeling of bugs under skin, paranoia and schizophrenia like state, exhaustion by lack of sleep and food, appetite, exhaustion, depression
cocaine
67
increase catecholinergic neurotransmitters
Amphetamines
68
dopamine not be metabolized thus released
Amphetamines
69
treat narcolepsy and ADHD
Amphetamines
70
managed by benzodiazepines
Amphetamines
71
related drugs (shabu, ecstasy)
Amphetamines
72
- “raves” designer drug - SERT
Ecstasy
73
Methylene dioxymethamphetamine (MDMA)
Ecstasy
74
reverse the effects of fatigue on both mental and physical tasks.
Stimulants
75
strong psychological and physiological dependence (more addictive than heroin and cocaine)
Nicotine
76
receptors of caffeine
adenosine receptors

pcol (8 decks)

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