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pcol > Drug of Abuse > Flashcards

Drug of Abuse Flashcards

1
Q

Physical
Tolerance
Withdrawal Syndrome
Non psychoactive drugs

A

Dependence

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2
Q

Psychological
Compulsion
Relapsing
Craving

A

Addiction

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3
Q

High potential for abuse, no known medical use and lacks accepted safety for use
E.g Heroin, Lysergic acid diethylamide

A

Schedule I

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4
Q

Potential for abuse with proven and accepted medical use but WITH SEVERE RESTRICTIONS, because abuse may cause severe psycho/physio dependence
E.g morphine, cocaine, methadone, methampetamine, phencyclidine

A

Schedule II

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5
Q
  • Less potential for abuse than schedule I or II; with accepted medical use
  • Abuse may cause moderate or low physical dependence or high psychological dependence
  • Anabolic steroids, codeine and hydrocodone, with aspirin or Tylenol
A

Schedule III

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6
Q
  • The drug or other substance has a low potential for abuse relative to the drugs or other substances in Schedule III
  • Abuse of the drug or other substance may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in Schedule III
  • Valium and Xanax
A

Schedule IV

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7
Q
  • The drug or other substance has a low potential for abuse relative to the drugs or other substances in Schedule IV
  • Cough syrups and codeine
A

Schedule V

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8
Q

Reduction of concentration
Shorter duration of action

A

Pharmacokinetic Tolerance

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9
Q

Recruitment of Adaptor protein (β arrestin)
Desensitization
Receptor internalization

A

Pharmacodynamic Tolerance

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10
Q

Alter perception; no reward/euphoria
targets cortical and thalamic system

A

Nonaddictive Drug of Abuse

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11
Q

Hallucinogens
Dissociative anesthetics
LSD
PCP/Ketamine
Dextromethorphan

A

Nonaddictive Drug of Abuse

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12
Q

receptors of:
Opioids, Cannabinoids, GHB, LSD, Mescaline & Psilocybin

A

G protein coupled

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13
Q

receptors of:
Nicotine, Benzodiazepines, Alcohol, Ketamine & PCP Inhalants

A

Ionotropic receptors

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14
Q

receptors of:
Cocaine, Amphetamines, Ecstasy(MDMA)

A

Biogenic Amines

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15
Q

Strong analgesics

A

Opioids

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16
Q

morphine, codeine, thebaine, papaverine

A

Opiates

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17
Q

“sleep inducing”

A

Narcotic

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18
Q

affinity of mu

A

endorphins>enkephalins>dynorphins

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19
Q

affinity of delta

A

enkephalins>endorphins>dynorphins

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20
Q

affinity of kappa

A

dynorphins> endorphins and enkephalins

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21
Q

Papaver somniferum

A

Opium

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22
Q
  • powerful narcotic, painkiller
  • principal active ingredient is MORPHINE
A

Opioids

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23
Q

diamorphine

A

Heroin

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24
Q

an addictive drug as a white or brown powder

A

Heroin

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25
Q

half life of heroine

A

T1/2= 3 5 hrs, therefore several doses/ day

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26
Q

oxycodone is synthesized from

A

thebaine

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27
Q

oxycodone is derived from

A

codeine

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28
Q

serious interaction with MAO’s

A

Meperidine

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29
Q

attempts to illicitly produce meperidine
has resulted in MPTP which can cause

A

parkinsonism

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30
Q

increased CNS depression, particularly respiratory depression

A

sedative-hypnotics

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31
Q

increased sedation.
variable effects on respiratory depression.
accentuation of cardiovascular effects

A

antipsychotic agents

32
Q

relative contradiction to all opioid analgesics because of the high incidence of hyperpyrexic coma

A

monoamine oxidase inhibitors

33
Q

alcohol, barbiturates, benzodiazepines,
gamma hydroxybutyric acid (GHB)

A

Sedative - hypnotics

34
Q

true or false: in sedatives, the longer the duration the less the withdrawal

A

true

35
Q

rare occurrence of physiologic dependence

A

Benzodiazepines

36
Q

weight loss, change in perception,
paresthesia, headache

A

“Therapeutic Dose Dependence”

37
Q

used for date rape

A

Flunitrazepam (Rohypnol)

38
Q

causes anterograde amnesia

A

Flunitrazepam (Rohypnol)

39
Q
  • GABAa receptors
  • usually Short acting drugs
  • eg. Secobarbital, pentobarbital Na
A

Barbiturates

40
Q

withdrawal effects: motor agitation, anxiety, insomnia, hallucination, abnormal vital signs, seizures

A

Alcohol

41
Q
  • GABAb
  • naturally found in body
  • can be found in fermented drinks like guava (Psidium guajava)
  • liquid ecstasy, soap, easy lay, vita G
  • Georgia homeboy
A

Gamma Hydroxybutyric Acid

42
Q

withdrawal effects include:
insomnia, anxiety, tremors, sweating

A

Gamma Hydroxybutyric Acid

43
Q

use with alcohol can produce breathing
problems

A

Gamma Hydroxybutyric Acid

44
Q

treatment for for Short acting and Long acting drugs

A

chlordiazepoxide or phenobarbital

45
Q

treatment for alcohol

A

disulfiram, naltrexone

46
Q

Cannabis sativa

A

Marijuana

47
Q

cannabinol, tetrahydrocannabinol , cannabidiol

A

Cannabinoids

48
Q
  • antiemetic
  • tolerance
  • uncertain effect on fetus
  • Amotivational syndrome
  • diseases related to smoking
A

Cannabinoids

49
Q

substances that cause hallucinations

A

Hallucinogens

50
Q

LSD, PCP, Ketamine, Scopolamine are examples of what substance?

A

Hallucinogens

51
Q

synthetic agent related to ergot alkaloids

A

LSD

52
Q

NE, dopamine, serotonin

A

LSD

53
Q

5 HT1a & 5 HT1c agonists

A

LSD

54
Q

rise in body temp
Hallucinations
uterine contractions
elevated sugar levels
goosebumps
Euphoria
pupil dilation

are effects of what substance?

A

LSD

55
Q

Psilocybe mushroom

A

Psilocybin

56
Q

mydriasis, muscle relaxation, dizziness are effects of what substance?

A

Psilocybin

57
Q
  • anesthetic
    -“special K” “vitamin dream like states, hallucination, delirium, amnesia, high BP,
    depression, fatal respiratory problems
A

Ketamine

58
Q

phenylcyclohexamine deriv.

A

Phencyclidine (angel dust, PCP)

59
Q

veterinary anesthetic

A

Phencyclidine (angel dust, PCP)

60
Q

antagonize NMDA

A

Phencyclidine (angel dust, PCP)

61
Q

users tend to be violent and suicidal

A

Phencyclidine (angel dust, PCP)

62
Q

block central muscarinic receptors

A

Scopolamine

63
Q

dopaminergic reuptake transmitter

A

Cocaine

64
Q

inhibit reuptake of dopamine and NE

A

Cocaine

65
Q

half life of cocaine

A

t1/2= 1hr, repeated 30min

66
Q

symptoms include a feeling of bugs under skin, paranoia and schizophrenia like state, exhaustion by lack of sleep and food, appetite, exhaustion, depression

A

cocaine

67
Q

increase catecholinergic neurotransmitters

A

Amphetamines

68
Q

dopamine not be metabolized thus released

A

Amphetamines

69
Q

treat narcolepsy and ADHD

A

Amphetamines

70
Q

managed by benzodiazepines

A

Amphetamines

71
Q

related drugs (shabu, ecstasy)

A

Amphetamines

72
Q
  • “raves” designer drug
  • SERT
A

Ecstasy

73
Q

Methylene dioxymethamphetamine (MDMA)

A

Ecstasy

74
Q

reverse the effects of fatigue on both mental and physical tasks.

A

Stimulants

75
Q

strong psychological and physiological
dependence (more addictive than heroin
and cocaine)

A

Nicotine

76
Q

receptors of caffeine

A

adenosine receptors

pcol (8 decks)

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