drug names: final

Question 1

Cyclosporin A, Tacrolimus

Answer 1

Binding to specific protein co-factors. (CpN and FKBP respectively) then inhibits calcineurin (phosphatase that activates NF-AT which activate Tc cells)

Question 2

Chimeric Antigen Receptor T-Cell Therapy

Answer 2

Engineered cytotoxic T cells to target cancer

Question 3

Antimicrobial Peptides (AMP) and Pore-forming toxins

Answer 3

Cathelicidins and Defensins
Daptomycin
Melittin
Disrupt membranes by charge-charge interactions. AMPs are positive and bacterial membranes are negative. This helps bind them together.

A(dapt) to amp up for the defenses of the Catholic church ; we can use bees (they’re lit)

Question 4

Protein A

Answer 4

Binds IgG Fc domains to inhibit opsonization and phagocytosis, used by Staph

Question 5

Lymes Disease:

Answer 5

recruits protein H and CD59 mimic (lyme sounds like lie)

Question 6

HIV

Answer 6

incorporates CD59 into viral envelope, inhibiting MAC-mediated lysis

Question 7

Hereditary Angioedema

Answer 7

Defect in C1 inhibitor. Caused by upregulation of C4a and C2a

angie is the chinese 1 (c1)

Question 8

Systemic Lupus Erythematosus

Answer 8

Classical pathway defect. Usually clears immune complexes and apoptotic cells. Leads to autoantibody formation.

Question 9

Infliximab, Adalimumab

Answer 9

Monoclonal antibodies that inhibit TNF- alpha.

Question 10

Etanercept

Answer 10

Fusion protein with Fc domain that has TNF receptor.
Needs low-dose Methotrexate and adjunct.

ppl who are tanner like fusion food

Question 11

Reperfusion Injury:

Answer 11

Once deprived of oxygen, necrotic cells induce complement response that leads to runaway immune response.

Question 12

Complement-Focused Therapies:

Answer 12

Eculizumab (soliris) and Compstatin

compliments excludes (ecul) compton

Question 13

Eculizumab (soliris)

Answer 13

Anti-C5 antibody for post-MI.

Question 14

Compstatin

Answer 14

C3 Inhibitor, proposed for macular degeneration and psoriasis