22-23 coag

Question 1

hemostasis definition

Answer 1

• maintenance of fluid state of blood

- balanced btwn procoag, anticoag, fibrinolysis

Question 2

5 stages of coag

Answer 2

1) vasoconstriction
2) formation of hemostatic plug
3) formation of blood clot
4) control of coag
5) fibrinolysis

Question 3

vasoconstriction involves

Answer 3

NS, endothelin, collagen

Question 4

vasoconstriction purpose

Answer 4

• limit blood flow

- allows localization of platelets/clotting factors

Question 5

endothelin function in vasoconstriction

Answer 5

• peptide hormone
• constricts blood vessels
• raises BP
• along with NS, triggers vascular spasm

Question 6

NS function in vasoconstriction

Answer 6

along with endothelin, triggers vascular spasm

Question 7

collagen function in vasoconstriction

Answer 7

triggers subsequent phases of coag

Question 8

3 steps to form hemostatic plug

Answer 8

adhesion, activation, aggregation

Question 9

adhesion (hemostatic plug formation) involves

Answer 9

collagen, vWF

Question 10

collagen function in adhesion (hemostatic plug formation)

Answer 10

binding site for platelets

Question 11

vWF function in adhesion (hemostatic plug formation)

Answer 11

enhances collagen:platelet binding

Question 12

activation (hemostatic plug formation) involves

Answer 12

platelets, which release:

ADP, 5-HT (seratonin), thromboxane A2 (T2A2), platelet factors

Question 13

activation (hemostatic plug formation) purpose

Answer 13

formation of “sticky platelets”, will bind to each other in aggregation