Drug Interactions Part A

Question 1

Use of multiple drugs

Answer 1

Polypharmacy

Question 2

When drugs work against each other.

Answer 2

Antagonism

Question 3

When drugs work with each other.

Answer 3

Synergism

Question 4

Types of synergism

Answer 4

1) Additive

2) Potentiation

Question 5

These decrease the absorption of Tetracyclines and other drugs.

Answer 5

Antacids and Metamucil

Question 6

Acidic things like grapefruit, mango, papaya, and guava increase or decrease absorption of drugs?

Answer 6

Increase

Question 7

Hydrolyzes Penicillin

Answer 7

Acids in fruit juice

Question 8

Foods that cause drug interactions.

Answer 8

1) Grapefruit juice
2) Iron
3) Calcium
4) Antacids
5) Metamucil

Question 9

Barbiturates affect which organ and what does it cause in that organ?

Answer 9

Liver

Increase the enzyme activity of hepatocytes.

Question 10

Drugs that are metabolized faster when taking barbiturates.

Answer 10

• Anticoagulants
• Phenytoin
• Tricyclics
• Corticosteroids
• Monoamine oxidase inhibitors.

Question 11

How do you increase the onset of a drug?

Answer 11

Put it in the LIQUID form.

Question 12

Drugs that have additive effects.

Answer 12

1) Sedatives and Hypnotics
2) Tranquilizers
3) Alcohol
4) Calcium channel blockers and Cyclosporin (both cause gingival enlargement)
5) Antihistamines
6) Narcotic analgesics
7) Tricyclic antidepressants

Question 13

T/F:

Don’t give bacteriostatic drugs with bactericidal drugs, because they work in opposite ways.

Answer 13

True

Question 14

Example of antibiotic antagonism.

Answer 14

Pencillin and Tetracycline

Question 15

Do antihistamines and epi antagonize or synergize?

Answer 15

Antagonize bc antihistamine is a vasodilator, and epi is a vasoconstrictor.