Drug Interactions

Question 1

UGT1A1 inducers: Anticonvulsants

Answer 1

carbamazepine, phenytoin, phenobarbital, Lamotrigine, primidone

Question 2

UGT1A1 inducers: hormones (3)

Answer 2

Ethinyl estradiol, Desogestrel, testosterone propionate

Question 3

UGT1A1: anti-infectives

Answer 3

Efavirenz, Nelfinavir, rifampicin, ritonavir, Tipranavir, zidovudine

Question 4

What are the primary drug interaction considerations for methadone? (3)

Answer 4

QTc prolongation
CYP3A4
CYP2D6

Question 5

2C9 inhibitors

Answer 5

Amiodarone.
Fluoxetine.
Fluconazole.
Metronidazole
Trimethoprim/sulfamethoxazole
Ritonavir

Question 6

3A4 inducers

Answer 6

Phenobarbital.
Phenytoin.
Rifampin.
St. John’s wort

Question 7

3A4 inhibitors

Answer 7

Clarithromycin, Erythromycin
Diltiazem, verapamil
Itraconazole, Ketoconazole.
Ritonavir

Question 8

Amiodarone inhibits which drug metabolizing enzyme systems?

Answer 8

2C9, 2D6, 3A4

Question 9

Dofetilide is a substrate of which drug metabolizing enzymes?

Answer 9

3A4

Question 10

Which medications are contraindicated in patients taking dofetilide?

Answer 10

Itraconazole, ketoconazole
Megesterol
Prochlorperazine
Thiazides
Trimethoprim

Question 11

Dronedarone is a substrate of which drug metabolizing enzyme system?

Answer 11

3A4

Question 12

Which medications are contraindicated in persons taking dronedarone ?

Answer 12

Clarithromycin, telithromycin
Itraconazole, ketoconazole,
Nefazodone
Ritonavir
voriconazole