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DISPENSING LEC (DRUG INTERACTION) > DRUG INTERACTION PART 1 > Flashcards

DRUG INTERACTION PART 1 Flashcards

1
Q

The drug whose activity is affected in the interaction.

A

Object Drug

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2
Q

The entity that triggers an interaction.

A

Precipitant

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3
Q

warfarin and aspirin

A

drug-drug interaction

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4
Q

ace inhibitor and k+ sparring

A

drug-drug interaction

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5
Q

Anti-biotic and oral contraception

A

drug-drug interaction

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6
Q

Digoxin and diuretics

A

drug-drug interaction

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7
Q

grapefruit and statins

A

drug food interaction

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8
Q

Spinach and warfarin

A

drug food interaction

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9
Q

dairy product and anti biotic

A

drug food interaction

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10
Q

alcohol and pain killers

A

drug-food interaction

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11
Q

st. john wort and antidepressant

A

drug-herb interaction

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12
Q

gingko biloba and blood thinners

A

drug-herb interaction

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13
Q

ginseng and blood pressure medication

A

drug-herb interaction

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14
Q

garlic and blood thinners

A

drug-herb interaction

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15
Q

biotin and troponin level test

A

drug-laboratory test interaction

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16
Q

Aspirin and liver fxn test

A

drug-laboratory test interaction

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17
Q

Diuretics and electrolytes

A

drug-laboratory test interaction

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18
Q

what is the bacteria present in yakult?

A

probiotic : Lactobacillus casei Shirota

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19
Q

Beta blocker and asthma

A

drug -dse interaction

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20
Q

Nsaids and peptic ulcer dse

A

drug -dse interaction

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21
Q

anti cholinergic and glaucoma

A

drug -dse interaction

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22
Q

Antacid and tetracycline

A

drug -chemical interaction

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23
Q

chlorine and nitrate meds

A

drug -chemical interaction

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24
Q

alcohol and disulfiram

A

drug -chemical interaction

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25
Q

antibiotic and water pollution

A

drug - environment interaction

26
Q

cold weather and beta blockers

A

drug - environment interaction

27
Q

sunlight and tetracycline

A

drug - environment interaction

28
Q

effects of DI:
-increased or decreased effect.
-Enzyme inhibition or induction

A

Generally quantitative-

29
Q

Seldom qualitative

A

-Rapid or slower effect.
-Synergism or antagonism

30
Q

precipitation

A

-New or increased adverse effects.
-harmful

31
Q

desirable or undesirable:
Alaxan® is made up of paracetamol
and ibuprofen.

A

beneficial; This would be beneficial in the
management of pain and prevent inflammation,
respectively by its components of paracetamol
and ibuprofen.

32
Q

CONTRIBUTING FACTORS:
2 or more drugs that are being taken by a
patient.

A

Polypharmacy

33
Q

CONTRIBUTING FACTORS:
there is now a cumulation of drugs from the first
and second physician.

A

Multiple Physicians

34
Q

CONTRIBUTING FACTORS:
Aspirin has several pharmacological effects
such as anti-inflammatory, antithrombotic, analgesic,
anticancer

A

Multiple Pharmacologic Effects

35
Q

CONTRIBUTING FACTORS:
illness of the patient becomes more

A

Multiple Disease/Predisposing Illness

36
Q

CONTRIBUTING FACTORS:
Patient doubles the amount of drug that would
be taken with the notion that higher doses would give better effects.

A

Poor Patient Compliance

37
Q

CONTRIBUTING FACTORS: As patients age, they might become forgetful.

A

Advancing Age of Patient

38
Q

CONTRIBUTING FACTORS: drug has low therapeutic index

A

Drug Related Factor

39
Q

in vitro; occurs BEFORE drugs are administered

A

pharmaceutical interaction

40
Q

pharmaceutical interaction

A

o Physical incompatibilities
o Chemical incompatibilities

41
Q

In vivo; occurs AFTER drugs are administered

A

pharmacological interaction

42
Q

pharmacological interaction

A

-PHARMACOKINETICS
-PHARMACODYNAMICS

43
Q

ADME

A

PHARMACOKIETICS

44
Q

SYNERGISM, POTENTIATION, ADDITION AND ANTAGONISM

A

PHARMACODYNAMIC

45
Q

Complexation
and adsorption

A

ABSORPTION INTERACTION

46
Q

Altered in
Gastrointestinal
(GI) pH

A

ABSORPTION INTERACTION

47
Q

Alteration in
GUT motility

A

ABSORPTION INTERACTION

48
Q

Inhibition of GI
enzymes

A

ABSORPTION INTERACTION

49
Q

Alteration in GI
flora

A

ABSORPTION INTERACTION

50
Q

Malabsorption
Syndrome

A

ABSORPTION INTERACTION

51
Q

ASA (aspirin) +
Warfarin=Bleeding/hemorrhage due to displacement of warfarin since it is less protein bound

A

Distribution interactions

52
Q

more enzymes are produced. Faster metabolism- Decrease in the pharmacological effect of the object drug

A

Enzyme induction; madaling ma excreet

53
Q

Slower metabolism; Greater concentration of
the drug in the blood. Resulting to more

A

Enzyme inhibition; madaling maabsorb

54
Q

Alteration in
renal blood
flow

A

Excretion interactions

55
Q

Alteration
urine pH

A

Excretion interactions

56
Q

Competition for active
secretions

A

Excretion interactions

57
Q

Forced
diuresis

A

Excretion interactions

58
Q

taking one stimulant or CNS stimulant with another stimulant would
result to an increase stimulant action
resulting form the sum of its individual
drug

A

Addition or
summation

59
Q

1+1=0

A

antagonism

60
Q

Remdesivir (antiviral
agent) is taken with clarithromycin
(microlide antibiotic)

61
Q

aspirin and
warfarin resulting to
bleeding/hemorrhage

A

potentiation

DISPENSING LEC (DRUG INTERACTION) (7 decks)

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