Drug eruptions Flashcards
2 features of urticarial eruption
itchy red wheals
angioedema
What type of hypersensitivity reaction is urticaria?
type 1 IgE-mediated
How can urticarial eruption be diagnosed?
skin prick test
Treatment for urtucarial eruption
anti-histamines
4 drug causes of urticarial eruption
NSAIDs
Beta-lactam antibiotics
Opiates
ACE-inhbitors
How does morbilliform eruption present?
generalised maculopapular rash
What type of hypersensitivity reaction is morbilliform eruption?
type 4 T-cell mediated
(delay of 1-2 weeks between drug and rash)
4 drug causes of morbilliform eruption
Amoxicillin (especially if patient infected with EBV)
Beta-lactam antibiotics
Sulphonamides
Allopurinol
How does fixed drug eruption present?
circular, erythematous patches
may contain a blister
recur in same location every time drug is taken
pigmentation may remain after healing
3 drug causes of fixed drg reaction
Paracetamol
Sulfomanides
Tetracycline antibiotics
How does lichenoid eruption present?
similar to lichen planus, although more commonly affects trunk and Wickham’s striae usually absent
Purple, pruritic, polygonal, planar papules/plaques
Longitudinal ridging may be seen in nails
Typically presents 2 months after starting medication
6 drug causes of lichenoid eruption
Beta-blockers
Thiazides
Ace-inhibitors
Antimalarials
Gold
Penicillamine
