Drug Elimination Flashcards
What is the minimum effective concentration?
critical concentration in the plasma
What is the maximum tolerated concentration?
conc at which drug causes significant unwanted effects
What is pharmacokinetics?
mathematical analysis of all drug disposition factors
Most drugs take up first order kinetics which means what?
rate of elimination is directly proportional to drug concentration
What is clearance?
volume of plasma cleared of drug per unit time
What is volume of distribution?
volume into which a drug appears to have equal concentration to that of plasma
Why is a loading dose used?
to decrease time to steady state for drugs with long half lives
What is half life?
the time taken for a drugs concentration in the plasma to halve
What happens in zero order kinetics?
drug is eliminated originally at a constant rate independent of concentration of it
