Biochemical Basis for Therapy Flashcards
What are receptors?
sensing elements in the complex system of chemical communication within the body
What are the 4 major types of receptor?
G-coupled protein receptor, kinase linked, nuclear, ligand gated ion channel
Nuclear receptors are generally targeted by what sort of molecule?
hydrophobic
Ligand gated ion channels are regarded as what by pharmacologist?
true receptors
Nicotinic Ach is what type of true receptor?
pentameric
Ligand gated ion channels are made up of what sort of subunit?
glycoproteins
Describe secondary messenger system
receptor activation modulates the activity of an effector that is generally an enzyme
How many times does a G-protein linked receptor span membrane?
7
G-protein linked receptor is what sort of receptor?
integral membrane
G protein is what sort of protein?
peripheral
How many polypeptide units is a g-protein made up of?
3 - alpha, beta and gamma
What occupies alpha subunit when g-protein receptor is inactive?
GDP
What does activation of G-protein receptor cause on on G-protein?
Conformational change
What is transferred for GDP upon activation?
GTP
Phosphorylation of what produces cellular effects?
Ser/Thr residues in target proteins
