Drug/Drug interaction > 4

Question 1

Cyclophosphamide

Answer 1

Rifampin and phenytoin

Corticosteroids / TCAs /
allopurinol

succinylcholine

Question 2

Digoxin

Answer 2

loop or thiazide diuretics, amiodarone, calcium
channel blockers, spironolactone and
quinine

Question 3

Dipyridamole

Answer 3

adenosine.

Bleeding risk increases when taken with antiplatelet or
anticoagulant medicine

Question 4

Diuretics
Loop

Answer 4

reduce lithium excretion

digoxin toxicity risk increases

aminoglycosides

Question 5

Diuretics

Potassium-sparing
Amiloride

Answer 5

potassium-elevating drugs /supplements.

Renal clearance of lithium / digoxin reduced

Question 6

Diuretics
Thiazide (-like)

Answer 6

NSAIDs

Question 7

Dopaminergic drugs

Parkinson’s disease
Levodopa
Ropinirole
Pramipexole

Answer 7

antipsychotics, particularly typical antipsychotics.

Question 8

Emollients

Aqueous cream
Liquid paraffin

Answer 8

No clinically significant drug interactions

Question 9

Fibrates

Fenofibrate

Answer 9

Bile acid sequestrants
(eg. Cholestyramine)

cyclosporine

with warfarin

Increased risk of myopathies with statins.