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Dispensing 2 > Drug/Drug interaction > 2 > Flashcards

Drug/Drug interaction > 2 Flashcards

1
Q

Amiodarone

A

inc. plasma conc of digoxin, diltiazem, verapamil

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2
Q

ACE inhibitors

A

Hyperkalemia- other K elevating drugs/supplements

NSAIDs (renal)

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3
Q

Amphotericin B

A

Flucytosine toxicity

Cisplatin/ diuretics (renal)

Corticosteroids (hypokalemia)

aminoglycosides/nephrotoxic drugs (renal)

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4
Q

ARBs

A

Hyperkalemia- other K elevating drugs/supplements

NSAIDs (renal)

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5
Q

Antidepressants: SSRIs

A

MAO inhibitors (serotonin syndrome)

Anticoagulants

Macrolides, quinine, antipsychotics

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6
Q

Antidepressants: tricyclic related drugs

A

MAO inhibitors

TCA

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7
Q

Antiemetics/ H1 antagonist

A

Sedative drugs

Ipatropium, tiotropium

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8
Q

Prochlorperazine
Chlorpromazine

A

antipsychotics,
quinine,
SSRIs,
macrolides,
fluoroquinolones
ciprofloxacin.

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9
Q

Antifungal drugs- Fluconazole

A

inhibits CYP enzymes – increasing plasma concentration of phenytoin, carbamazepine, warfarin, simvastatin and sulfonylureas.

Clopidogrel (re. e antiplatelet effect)

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10
Q

Antihistamine- H1 antagonists

A

Cetirizine / Loratadine /
Fexofenadine

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11
Q

Antimotility Drugs- Loperamide

A

P-glycoprotein inhibitors- quinidine,
ritonavir and
ketoconazole

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12
Q

Antimuscarinics
Bronchodilators
Ipratropium / tiotropium

A

reduces risk of any major drug interactions.

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13
Q

Antimuscarinics

Cardiovascular
Atropine
Hyoscine butylbromide
Genito-urinary
Oxybutynin
Tolterodine
Solifenacin

A

more pronounced when
taken with other drugs
with the same effects,
such as tricyclic
antidepressants

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14
Q

Antipsychotics

Typical drugs
Atypical drugs

A

Avoid with
dopamine-blocking antiemetics.

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15
Q

Aspirin

A

Antiplatelets and
anticoagulant drugs
increase risk of bleeding

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16
Q

Benzodiazepines

A

alcohol and opioid

CYP inhibitors - macrolides, fluconazole,
amiodarone and protease inhibitors

17
Q

Beta-2 agonists

A

Corticosteroids increase risk of hypokalemia.

18
Q

Beta blockers

A

Avoid with non-dihydropyridine calcium
channel blockers – such as verapamil

Dispensing 2 (10 decks)

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