Drug-drug

Question 1

H2 antagonists

Answer 1

Decreased metabolism/increase toxicity of other drugs

Question 2

Antacids

Answer 2

1 hr before/2 hr after other drugs- affects absorption of other drugs

Question 3

PPIs

Answer 3

Increased toxicity of warfarin, benzodiazepines, and phenytoin

Decreased levels of ketoconazole and theophylline

Decreased PPI absorption with sucralfate

Increased CV effects with clopidogrel

Question 4

GI protectant

Answer 4

Aluminum salts

Question 5

Chemical stimulants

Answer 5

Take 30 min before/after other drugs- decreases absorption of other drugs

Question 6

Bulk stimulants

Answer 6

30 min before/after- decreased absorption of other drugs

Question 7

Osmotic laxatives

Answer 7

30 min before/after- decreased absorption of other drugs

Mg: neuromuscular junction blockers

Question 8

Lubricants

Answer 8

Decrease absorption of fat soluble vitamins (A, D, E, K)

Question 9

GI stimulants

Answer 9

Decreases digoxin absorption
Increased activity of cyclosporin
Increased sedation with alcohol

Question 10

Phenothiazines

Answer 10

Other CNS depressants, alcohol

Question 11

Substance P/Neurokinin 1 receptor antagonists

Answer 11

Decreased level of warfarin
Decreased effectiveness of hormonal contraceptives