Adverse Flashcards
H2 antagonists
GI, CNS
HypoT, arrhythmias
Antacids
Rebound acidity
Alkalosis
Constipation, diarrhea
HyperCa, hypophosphatemia
PPIs
CNS, GI
Upper respiratory: cough, stuffy, hoarse, epistaxis (nosebleed)
GI protectant
GI, CNS
Dry mouth
Prostaglandin
Mainly GI
GU (increased bleed, irregular menses)
Causes abortions
Digestive enzymes
GI
Abnormal electrolytes
Chemical stimulants
GI, CNS
Sweat, palpitations, flushing, fainting
Cathartic dependence
(Castor oil) blocks fat soluble vitamin absorption
Bulk stimulants
GI, CNS
Sweat, palpitations, flushing, fainting
Osmotic laxatives
GI, CNS
Sweat, palpitations, flushing, fainting
Dehydration, dry mouth
Lubricants
GI, CNS
Sweat, palpitations, flushing, fainting
(Mineral oil) leakage and staining
GI stimulants
GI
CV (decreased BP and HR)
Weakness, fatigue
Antidiarrheal
GI
Fatigue, weak, dizzy
Phenothiazines
CNS, photophobia
CV: hypoT, hyperT, arrhythmia
GU: menstrual disorders, galactorrhea (milk), gynecomastia (swelling)
Nonphenothiazines
CNS
Extrapyramidal (involuntary movements): dystonia (spasms), akathisia (restless), dyskinesia (jerky movements), parkinsonism (slowness and rigidity)
5-HT3 Receptor Blockers
HA, dizzy,
myalgia (muscle pain),
constipation
Substance P/Neurokinin 1 receptor antagonists
Anorexia, constipation, diarrhea,
increased liver enzymes,
dehydration, fatigue
Interferons
Most common: lethargy, myalgia, arthralgia
Nausea
HA, dizzy
Anorexia
Bone marrow depression
Interleukins
Most common: flu like symptoms (lethargy, myalgia, arthralgia, fatigue, fever)
Respiratory difficulties, depression with suicidal thoughts
Colony stimulating factors
Most common: generalized pain and bone pain
GI
HA, fatigue, weakness
Alopecia
Dermatitis (eczema)
Immune modulators
Unknown
T and B suppressors
Increased risk of infection
Increased risk of neoplasm (tumor)
Hepatotoxicity
Renal toxicity and dysfunction
Pulmonary edema
Interleukin antagonist
Nausea, diarrhea
HA
Sinusitis
Monoclonal antibody
Flu like
Pulmonary edema
Fluid retention
Salicylates
Stomach and clotting
Do not use for fever for kids- Reye Syndrome
NSAID
GI, GI pain and bleed
Dyspepsia (indigestion)
Somnolence (drowsy), dizzy
Platelet inhibition
HTN
Bone marrow suppression with chronic use
Acetaminophen
HA
Fever
Rash
Anemia
Renal dysfunction
Hepatotoxic with OD and chronic use
Gold compounds
Stomatitis/glossitis/gingivitis
Bone marrow depression
Dermatitis
Interstitial pneumonia
Anaphylactic shock
TNF blockers
Risk of fatal infection and development of lymphoma and cancer
Glucocorticoid
Increase glucose
Lots: GI, CNS, HF, fluid retention, osteoporosis, frail skin that won’t heal quickly
Cushing
Impaired child growth
Mineralocorticoids
Increase fluid volumes
HypoK
Antitussives
Dries mucous membranes
CNS drowsy, HA, dizzy
GI nausea, constipation
Topical nasal decongestant
Sting and burn
Rebound congestion
SNS effects
Oral decongestants
Rebound congestion
SNS effects
Topical nasal steroid decongestants
Burn and sting
Dry mucous membranes
HA
Decreased healing
Antihistamines
CNS drowsy
Anticholinergic dry, nausea, urine hesitation
CV arrhythmia
Expectorants
GI
CNS HA and dizzy
Rash
Masking
Mucolytics
GI
Stomatitis
Rhinorrhea (runny nose)
Bronchospasm
Rash at nebulizer area
Xanthines
GI
Irritated
Tachycardia
Hyperglycemia
Seizure
Brain damage and death
Sympathomimetics
SNS
CNS
GI
Bronchospasm
Cardiac - arrhythmia, hypertension, sweat, pallor, flushing
Anticholinergic
Can’t see spit poop pee
CNS dizzy, HA, nervous, fatigue, sore throat, retention, palpitations
Inhaled steroids
Sore throat, hoarseness, coughing
Dry mouth, throat infections
Leukotriene receptor antagonists
URI, pharyngitis, cough
CNS dizzy and HA
GI and increased liver enzymes
Pain, fever, myalgia
Grouchy kids
Lung surfactants
Unknown
Nitrates
Related to vasodilation and decreased blood flow
2 biggies: Hypotension and HA
Also GI, flush, pallor, sweat
Beta blockers
Related to SNS blocking
Hypotension and bradycardia
GI
CNS dizzy, fatigue, depression
CV CHF, decreased CO, arrhythmia
Respiratory- bronchospasm, dyspnea, cough
Calcium channel blockers
Most common: hypotension, arrhythmia
GI
Skin
HA
Cardiac glycosides
CNS HA, weak, drowsy, yellow halo
GI anorexia
Brady arrhythmias
Phosphodiesterase inhibitors
Most common: arrhythmias, hypotension, GI, thrombocytopenia (reduced platelets)
HCN channel blockers
Biggest one: bradycardia
HyperT, atrial fibrillation, luminous phenomena (sudden vision changes)
Class 1
CNS dizzy and fatigue (common), slurred
GI nausea and vomiting
CV arrhythmia (common)
Respiratory depression
Rash, hair loss, potential bone marrow suppression
Class 2
Related to SNS block
CNS dizzy, insomnia, dream, fatigue (common)
CV hypotension and bradycardia (common), AV block, arrhythmia
Respiratory bronchospasm and dyspnea
GI nausea, vomiting, anorexia
Decreased libido and exercise tolerance
Altered blood glucose
Class 3
GI nausea and vomiting
CNS weak and dizzy
CV arrhythmia
Class 4
Common: dizzy, weak, fatigue
Depression
GI
HypoT, CHF, shock