DRUG DOSING AND SELF POISONING

Question 1

HOW DO SSRI’S WORK?

Answer 1

• Block the reuptake of serotonin = more serotonin to bind to the post synaptic receptors

Question 2

VENLAFAXINE AND DESVENLAFAXINE CONSIDERATIONS

Answer 2

Both SNRI’s
Serotin and norad reuptake inhibitors
have cardiotoxic/sodium channel blocking activity

Question 3

What are MAOI’s

Answer 3

• Mitochondrial enzyme that degrades NT’s such as serotonin and NAD
• Distributed between brain, gut and liver
• Inhibit the enzymes breakdown of NT’s = increase levels of NT’s

Question 4

AMIODARONE- how does it work

Answer 4

• Increases refractory period in all cardiac tissues
• Decreases automaticity of fibres in purkinje system
• Prolongs AV conduction
• Blocks K+, na+ and Ca++ channels on beta receptors
• Side effects are hypotension and bradycardia

Question 5

why does giving adrenaline to quetiapine cause hypotension

Answer 5

• Causes alpha blockade, if we give adrenaline we can have a paradoxical effect
• Adrenaline is alpha and beta, and with alpha blockade there will be more beta, which will cause profound hypotension
• Not a complete contraindication, as only “some” have this paradoxical effect
• Consider pressors over adrenaline