Drug Distribution

Question 1

Drug distribution

Answer 1

after the drug has been absorbed into the body, it will have to makes it way to the intra and intercellular fluid from the circulatory system

Question 2

What does drug distribution depend on?

Answer 2

physiochemical properties of drug
degree of ionization
blood flow
patient related factors

Question 3

total body water

Answer 3

the water contents in the entire body

Question 4

Intracellular fluid

Answer 4

this is the water content of all the cells

Question 5

Extracellular fluid

Answer 5

Water contents that are outside the cells

Question 6

What falls under extracellular fluid

Answer 6

intravascular fluid (plasma) and interstitial fluid (bathe cells)

Question 7

Why is the extracellular fluid so important for drug distribution

Answer 7

because drug distribution is faster on the ECF

Question 8

Whole blood is composed of __________ suspended in _______

Answer 8

blood cells in plasma

Question 9

Volume of distribution

Answer 9

a measure of drug concentration in the plasma

Question 10

Formula for Vd

Answer 10

Vd= dose/Co (initial drug concentration)

Question 11

Measurements of Vd

Answer 11

L/kg or mL/Kg

Question 12

Dose measurements

Answer 12

g, mg, nanograms

Question 13

Initial plasma measurements

Answer 13

g,mg , ng, ml, l

Question 14

How is Vd and half life of drug related

Answer 14

The larger the Vd the longer the half life is

Question 15

What are the clinical applications of Vd

Answer 15

knowing the Vd can be used to calculate the dosage of drug required to achieve a desired plasma concentration

Question 16

What is adipose? What is the significance in relation to drug distribution?

Answer 16

Adipos is the fat in our body and highly lipophilic drugs will be able to distribute and accumulate there. This leads to reservoirs/ sites of accumulation of drug in the body, therefore extending the half life of the drug in the body

Question 17

What does the % of free drug in the body depend on?

Answer 17

Kd of drug
total drug concentration
albumin concentration

Question 18

What must be taken into consideration when determining drug- plasma protein binding

Answer 18

physiological properties
age
disease states
connection between drug and endogenous compounds
drug-drug interactions

Question 19

What are the implications of variability in adipose tissue

Answer 19

plasma concentration for lipid soluble drugs in individuals with higher fat % is lower than leaner individuals of the same weight

Question 20

Enterohepatic circulation

Answer 20

Drugs that are brought to liver and carried to stomach can be reabsorbed across intestine back to blood